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• W2571293079 abstract "Event Abstract Back to Event Efficacy and mechanism of action of intrahippocampal D-cycloserine in an animal model of post-traumatic stress disorder Lorren Fairbairn1*, Soraya Seedat1 and Willie Daniels2 1 University of Sellenbosch, Department of Psychiatry, South Africa 2 University of Kwazulu-Natal, South Africa Background: One of the most prevalent anxiety disorders is posttraumatic stress disorder (PTSD), of which current therapies are based on the processes of fear extinction. Specifically cognitive behaviour therapy (exposure-based) in humans is procedurally very analogous to extinction training in animal models of emotional learning [1].Recent studies have alluded to the mechanisms underlying fear extinction which in turn has given rise to the hypothesis that dysfunctional fear extinction plays a vital role in the development of PTSD pathophysiology. DCS and its facilitative effects are currently under investigation in clinical studies of PTSD in order to enhance fear extinction techniques. However, attempts to identify specific mechanisms by which DCS enhances loss of fear in humans have provided few insights. Considering the known impact of trauma and stress on early brain development, further studies need to be conducted in order to elucidate the mechanisms underlying PTSD symptomatology in adolescents. Aim: Therefore the proposed animal study aims to extend the current state of knowledge of the effects of DCS on anxiety reduction in adolescent and adult rats, hypothesizing that these are associated with adaptive learning. Methodology: Since associative fear conditioning and non-associative sensitization processes have been suggested as contributors towards exaggerated implicit fear memory [2], a PTSD model tapping into both of these fear components following the experience of a trauma, will be used. A brief but intense electric footshock will be applied [3]. Behaviour, neurotrophin levels, gene expression and protein synthesis will be measured.Results:Pending.Should be available in time for congress. Significance: The proposed study is of significant value in addressing the molecular mechanisms of PTSD in the context of the current limited availability of effective therapeutic strategies for fear extinction. References 1. Zarate et al. 1994. Psychiatry 57,133 – 141.2. Sorg et al., 1995. Stress and neuronal sensitization. In: Neurobiological and clinical consequences of stress. From normal adaptation to post-traumatic stress disorder. Philadelphia, New York; Lipponcott-Raven; pp. 83 – 102.3. Siegmund et al. 2007. J Psychiatric Research 41,848 – 860. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Fairbairn L, Seedat S and Daniels W (2009). Efficacy and mechanism of action of intrahippocampal D-cycloserine in an animal model of post-traumatic stress disorder. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.141 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Jun 2009; Published Online: 09 Jun 2009. * Correspondence: Lorren Fairbairn, University of Sellenbosch, Department of Psychiatry, Cape Town, South Africa, lf@sun.ac.za Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lorren Fairbairn Soraya Seedat Willie Daniels Google Lorren Fairbairn Soraya Seedat Willie Daniels Google Scholar Lorren Fairbairn Soraya Seedat Willie Daniels PubMed Lorren Fairbairn Soraya Seedat Willie Daniels Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2571293079 title "Efficacy and mechanism of action of intrahippocampal D-cycloserine in an animal model of post-traumatic stress disorder" @default.
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