Matches in SemOpenAlex for { <https://semopenalex.org/work/W2571305783> ?p ?o ?g. }
- W2571305783 endingPage "72.e13" @default.
- W2571305783 startingPage "59" @default.
- W2571305783 abstract "Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the mRNA level from the wild-type and chimeric MLL alleles, the chimeric protein is more stable. We report that UBE2O functions in regulating the stability of wild-type MLL in response to interleukin-1 signaling. Targeting wild-type MLL degradation impedes MLL leukemia cell proliferation, and it downregulates a specific group of target genes of the MLL chimeras and their oncogenic cofactor, the super elongation complex. Pharmacologically inhibiting this pathway substantially delays progression, and it improves survival of murine leukemia through stabilizing wild-type MLL protein, which displaces the MLL chimera from some of its target genes and, therefore, relieves the cellular oncogenic addiction to MLL chimeras. Stabilization of MLL provides us with a paradigm in the development of therapies for aggressive MLL leukemia and perhaps for other cancers caused by translocations." @default.
- W2571305783 created "2017-01-13" @default.
- W2571305783 creator A5009711725 @default.
- W2571305783 creator A5010047624 @default.
- W2571305783 creator A5019985517 @default.
- W2571305783 creator A5020145193 @default.
- W2571305783 creator A5022001919 @default.
- W2571305783 creator A5027320272 @default.
- W2571305783 creator A5029331756 @default.
- W2571305783 creator A5034566006 @default.
- W2571305783 creator A5043822848 @default.
- W2571305783 creator A5047935699 @default.
- W2571305783 creator A5058560687 @default.
- W2571305783 creator A5060369063 @default.
- W2571305783 creator A5060639948 @default.
- W2571305783 creator A5069631252 @default.
- W2571305783 creator A5079900802 @default.
- W2571305783 creator A5091905526 @default.
- W2571305783 date "2017-01-01" @default.
- W2571305783 modified "2023-10-17" @default.
- W2571305783 title "Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia" @default.
- W2571305783 cites W1608885078 @default.
- W2571305783 cites W1965917470 @default.
- W2571305783 cites W1976033223 @default.
- W2571305783 cites W1979515634 @default.
- W2571305783 cites W1994275338 @default.
- W2571305783 cites W1998899452 @default.
- W2571305783 cites W2018317651 @default.
- W2571305783 cites W2021856943 @default.
- W2571305783 cites W2027913461 @default.
- W2571305783 cites W2040675004 @default.
- W2571305783 cites W2040909468 @default.
- W2571305783 cites W2059171174 @default.
- W2571305783 cites W2061433452 @default.
- W2571305783 cites W2062134218 @default.
- W2571305783 cites W2063738914 @default.
- W2571305783 cites W2073652391 @default.
- W2571305783 cites W2077015232 @default.
- W2571305783 cites W2077332810 @default.
- W2571305783 cites W2077457197 @default.
- W2571305783 cites W2080365007 @default.
- W2571305783 cites W2085092579 @default.
- W2571305783 cites W2087214029 @default.
- W2571305783 cites W2091938363 @default.
- W2571305783 cites W2099984271 @default.
- W2571305783 cites W2101782876 @default.
- W2571305783 cites W2105337626 @default.
- W2571305783 cites W2108453860 @default.
- W2571305783 cites W2108498698 @default.
- W2571305783 cites W2114104545 @default.
- W2571305783 cites W2120478300 @default.
- W2571305783 cites W2121910267 @default.
- W2571305783 cites W2123416522 @default.
- W2571305783 cites W2123810432 @default.
- W2571305783 cites W2124985265 @default.
- W2571305783 cites W2126917138 @default.
- W2571305783 cites W2130020386 @default.
- W2571305783 cites W2132742038 @default.
- W2571305783 cites W2140729960 @default.
- W2571305783 cites W2145289459 @default.
- W2571305783 cites W2147138024 @default.
- W2571305783 cites W2147713614 @default.
- W2571305783 cites W2151718828 @default.
- W2571305783 cites W2155235322 @default.
- W2571305783 cites W2162520885 @default.
- W2571305783 cites W2171705583 @default.
- W2571305783 cites W2171808845 @default.
- W2571305783 cites W2185022366 @default.
- W2571305783 cites W2191641478 @default.
- W2571305783 cites W2205700110 @default.
- W2571305783 cites W2294796250 @default.
- W2571305783 cites W4246697467 @default.
- W2571305783 doi "https://doi.org/10.1016/j.cell.2016.12.011" @default.
- W2571305783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5351781" @default.
- W2571305783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28065413" @default.
- W2571305783 hasPublicationYear "2017" @default.
- W2571305783 type Work @default.
- W2571305783 sameAs 2571305783 @default.
- W2571305783 citedByCount "92" @default.
- W2571305783 countsByYear W25713057832017 @default.
- W2571305783 countsByYear W25713057832018 @default.
- W2571305783 countsByYear W25713057832019 @default.
- W2571305783 countsByYear W25713057832020 @default.
- W2571305783 countsByYear W25713057832021 @default.
- W2571305783 countsByYear W25713057832022 @default.
- W2571305783 countsByYear W25713057832023 @default.
- W2571305783 crossrefType "journal-article" @default.
- W2571305783 hasAuthorship W2571305783A5009711725 @default.
- W2571305783 hasAuthorship W2571305783A5010047624 @default.
- W2571305783 hasAuthorship W2571305783A5019985517 @default.
- W2571305783 hasAuthorship W2571305783A5020145193 @default.
- W2571305783 hasAuthorship W2571305783A5022001919 @default.
- W2571305783 hasAuthorship W2571305783A5027320272 @default.
- W2571305783 hasAuthorship W2571305783A5029331756 @default.
- W2571305783 hasAuthorship W2571305783A5034566006 @default.
- W2571305783 hasAuthorship W2571305783A5043822848 @default.
- W2571305783 hasAuthorship W2571305783A5047935699 @default.
- W2571305783 hasAuthorship W2571305783A5058560687 @default.