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- W2571394115 abstract "The aqueous leaf extract of Byrsocarpus coccineus Schum and Thonn. (Connaraceae), ABC, was investigated for antipyretic activity in rats and rabbits using yeast [1], amphetamine [2] and lipopolysaccharide [3] induced pyrexia models. In control rats, yeast (10 mL/kg, s.c.) caused elevation of rectal temperature of 1.7oC 19h after administration. The extract (100, 200 and 400mg/kg, p.o.) produced a significant (p<0.05) dose dependent inhibition of temperature elevation. Peak inhibitory effect was observed at 1h post therapy (42.1, 47.2 and 63.6% inhibition, respectively for ABC at 100, 200 and 400mg/kg). The effect at 400mg/kg was greater than that of acetylsalicylic acid, ASA (100mg/kg, p.o.; 43.2%). An elevation in rectal temperature of 1.9oC was provoked in control rats by amphetamine (10mg/kg, i.p.) 0.5h after administration while in control rabbits, lipopolysaccharide from E. coli (0.2µg/kg, i.v.) elicited an elevation of 1.1oC, 1.5h post challenge. In both models, ABC produced a significant (p<0.05) dose and time dependent direct reduction of elevated temperature with peak effect observed at 3.5h post therapy. Percent reduction of fever values were 50.2, 61.1 and 84.3, respectively for ABC at 100, 200 and 400mg/kg (p.o.) in respect of the amphetamine test. The effect at 400mg/kg was about the same as that of ASA (85.3%) in this case, but it was lower (44.9%) compared to the standard drug (96.6%) in the lipopolysaccharide test. The results obtained in this study suggest that the extract possesses antipyretic activity." @default.
- W2571394115 created "2017-01-13" @default.
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- W2571394115 date "2006-08-24" @default.
- W2571394115 modified "2023-10-18" @default.
- W2571394115 title "Antipyretic activity of the aqueous leaf extract of Byrsocarpus coccineus" @default.
- W2571394115 doi "https://doi.org/10.1055/s-2006-950107" @default.
- W2571394115 hasPublicationYear "2006" @default.
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