Matches in SemOpenAlex for { <https://semopenalex.org/work/W2571778709> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2571778709 abstract "Background: Cationic lipid complexes have been shown to predominantly target angiogenic endothelial cells of solid tumors. In order to realize a vascular targeting tumor therapy a novel compound was synthesized by encapsulation of the topoisomerase inhibitor camptothecin in cationic nanoparticles (EndoTag i -2). Here we studied tumor vascular targeting properties, antitumoral effects and mode of action of the novel compound. Material and methods: Tumor vascular targeting properties of fluorescently labelled EndoTag i -2 was investigated by in vivo microscopy using A-MEL-3 tumors grown in the dorsal skinfold chamber preparation. Therapeutic effects have been investigated in the s. c. LLC-1 carcinoma model and the L3.6pl human pancreatic cancer model implanted orthotopically in nude mice. Antivascular effects have been studied by histological investigation of tumor microvessel density and non invasive investigation of tumor blood flow by dynamic contrast enhanced MRI imaging (DCE-MRI). Results: EndoTag i -2 selectively targeted tumor microvessels as confirmed by quantitative fluorescence microscopy. Compared to controls EndoTag i -2 revealed remarkable antitumoral efficiency in s.c. LLC-1 carcinomas. Growth and metastasis of L3.6pl human pancreatic tumors was significantly inhibited by EndoTag i -2 treatment. Quantitative analysis of tumor microvessel density revealed significant reduction of microvessel density. DCE-MRI confirmed significant reduction of intratumoral vascular volume as well as tumor perfusion upon EndoTag i -2 treatment. Conclusion: Cationic lipid complexed camptothecin (EndoTag i -2) results in a markedly active antitumor agent based on an innovative vascular targeting approach. Einleitung Nach systemischer Applikation reichern sich kationische Nanopartikel (KNPs) selektiv am angiogenetischen Tumorendothel an und stellen damit attraktive Carrier fur den Transport von zytotoxischen Substanzen an das proliferierende Tumorendothel dar [1, 2]. Ziel der Studie war die Entwicklung und praklinische Untersuchung der antitumoralen Wirkung und des Wirkmechanismus von neuartigen kationischen Nanopartikeln, die als zytotoxische Substanz den Topoisomeraseinhibitor Camptothecin (CPT) enkapsulieren. Methodik Die intratumorale Verteilung und Bindung der fluoreszenz-markierten, Camptothecin beladenen kationischen Nanopartikel an das Tumorendothel wurde in A-MEL-3 Tumoren in transparenten" @default.
- W2571778709 created "2017-01-26" @default.
- W2571778709 creator A5025651702 @default.
- W2571778709 creator A5028261654 @default.
- W2571778709 creator A5048356727 @default.
- W2571778709 creator A5050230085 @default.
- W2571778709 creator A5053569033 @default.
- W2571778709 creator A5058420457 @default.
- W2571778709 creator A5076234765 @default.
- W2571778709 creator A5086608438 @default.
- W2571778709 date "2007-01-01" @default.
- W2571778709 modified "2023-09-23" @default.
- W2571778709 title "Camptothecin enkapsuliert in kationische Nanopartikel (EndoTAG £ -2) verbessert signifikant die antitumorale Effektivität durch einen antivaskulären Wirkmechanismus Cationic lipid complexed camptothecin (EndoTAG £ -2) improves antitumoral efficacy by tumor vascular targeting" @default.
- W2571778709 cites W1968968207 @default.
- W2571778709 cites W2040443361 @default.
- W2571778709 hasPublicationYear "2007" @default.
- W2571778709 type Work @default.
- W2571778709 sameAs 2571778709 @default.
- W2571778709 citedByCount "0" @default.
- W2571778709 crossrefType "journal-article" @default.
- W2571778709 hasAuthorship W2571778709A5025651702 @default.
- W2571778709 hasAuthorship W2571778709A5028261654 @default.
- W2571778709 hasAuthorship W2571778709A5048356727 @default.
- W2571778709 hasAuthorship W2571778709A5050230085 @default.
- W2571778709 hasAuthorship W2571778709A5053569033 @default.
- W2571778709 hasAuthorship W2571778709A5058420457 @default.
- W2571778709 hasAuthorship W2571778709A5076234765 @default.
- W2571778709 hasAuthorship W2571778709A5086608438 @default.
- W2571778709 hasConcept C121608353 @default.
- W2571778709 hasConcept C126322002 @default.
- W2571778709 hasConcept C142724271 @default.
- W2571778709 hasConcept C185592680 @default.
- W2571778709 hasConcept C203014093 @default.
- W2571778709 hasConcept C2779013556 @default.
- W2571778709 hasConcept C2779682216 @default.
- W2571778709 hasConcept C502942594 @default.
- W2571778709 hasConcept C553184892 @default.
- W2571778709 hasConcept C55493867 @default.
- W2571778709 hasConcept C71924100 @default.
- W2571778709 hasConceptScore W2571778709C121608353 @default.
- W2571778709 hasConceptScore W2571778709C126322002 @default.
- W2571778709 hasConceptScore W2571778709C142724271 @default.
- W2571778709 hasConceptScore W2571778709C185592680 @default.
- W2571778709 hasConceptScore W2571778709C203014093 @default.
- W2571778709 hasConceptScore W2571778709C2779013556 @default.
- W2571778709 hasConceptScore W2571778709C2779682216 @default.
- W2571778709 hasConceptScore W2571778709C502942594 @default.
- W2571778709 hasConceptScore W2571778709C553184892 @default.
- W2571778709 hasConceptScore W2571778709C55493867 @default.
- W2571778709 hasConceptScore W2571778709C71924100 @default.
- W2571778709 hasLocation W25717787091 @default.
- W2571778709 hasOpenAccess W2571778709 @default.
- W2571778709 hasPrimaryLocation W25717787091 @default.
- W2571778709 isParatext "false" @default.
- W2571778709 isRetracted "false" @default.
- W2571778709 magId "2571778709" @default.
- W2571778709 workType "article" @default.