Matches in SemOpenAlex for { <https://semopenalex.org/work/W2571828530> ?p ?o ?g. }
- W2571828530 abstract "T helper 9 (Th9) cells contribute to lung inflammation and allergy as sources of interleukin-9 (IL-9). However, the mechanisms by which IL-9/Th9 mediate immunopathology in the lung are unknown. Here we report an IL-9-driven positive feedback loop that reinforces allergic inflammation. We show that IL-9 increases IL-2 production by mast cells, which leads to expansion of CD25+ type 2 innate lymphoid cells (ILC2) and subsequent activation of Th9 cells. Blocking IL-9 or inhibiting CD117 (c-Kit) signalling counteracts the pathogenic effect of the described IL-9-mast cell-IL-2 signalling axis. Overproduction of IL-9 is observed in expectorates from cystic fibrosis (CF) patients, and a sex-specific variant of IL-9 is predictive of allergic reactions in female patients. Our results suggest that blocking IL-9 may be a therapeutic strategy to ameliorate inflammation associated with microbial colonization in the lung, and offers a plausible explanation for gender differences in clinical outcomes of patients with CF." @default.
- W2571828530 created "2017-01-26" @default.
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- W2571828530 date "2017-01-16" @default.
- W2571828530 modified "2023-09-28" @default.
- W2571828530 title "A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis" @default.
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