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- W2571984714 abstract "Abstract On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feeding by monitoring body composition, energy homeostasis, insulin sensitivity/signaling, nitrite content and gene expressions changes in the tissues. We found that body weight and fat content in KO mice were significantly higher while the respiratory exchange ratio (RER), volume of carbon dioxide (VCO 2 ), and heat production were lower as compared to WT mice. Furthermore, altered systemic glucose tolerance, tissue insulin signaling, hepatic gluconeogenesis, augmented hepatic lipids, adiposity, as well as gene expression regulating lipid synthesis, catabolism and efflux were evident in iNOS KO mice. Significant reduction in eNOS and nNOS gene expression, hepatic and adipose tissue nitrite content, circulatory nitrite was also observed. Oxygen consumption rate of mitochondrial respiration has remained unaltered in KO mice as measured using extracellular flux analyzer. Our findings establish a link between the NO status with systemic and tissue specific IR in iNOS KO mice at 5 weeks." @default.
- W2571984714 created "2017-01-26" @default.
- W2571984714 creator A5014854660 @default.
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- W2571984714 date "2017-01-20" @default.
- W2571984714 modified "2023-10-17" @default.
- W2571984714 title "Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance" @default.
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- W2571984714 cites W1976833226 @default.
- W2571984714 cites W1987287108 @default.
- W2571984714 cites W1989471394 @default.
- W2571984714 cites W1992659810 @default.
- W2571984714 cites W1992967451 @default.
- W2571984714 cites W1994602325 @default.
- W2571984714 cites W1997023449 @default.
- W2571984714 cites W2002454792 @default.
- W2571984714 cites W2004257395 @default.
- W2571984714 cites W2004580431 @default.
- W2571984714 cites W2006440723 @default.
- W2571984714 cites W2007650925 @default.
- W2571984714 cites W2012999911 @default.
- W2571984714 cites W2018422556 @default.
- W2571984714 cites W2034086375 @default.
- W2571984714 cites W2035784072 @default.
- W2571984714 cites W2038097846 @default.
- W2571984714 cites W2040732264 @default.
- W2571984714 cites W2049215298 @default.
- W2571984714 cites W2050380270 @default.
- W2571984714 cites W2052695206 @default.
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- W2571984714 cites W2065063113 @default.
- W2571984714 cites W2066847273 @default.
- W2571984714 cites W2069954048 @default.
- W2571984714 cites W2072407021 @default.
- W2571984714 cites W2072444809 @default.
- W2571984714 cites W2073081893 @default.
- W2571984714 cites W2078821762 @default.
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- W2571984714 cites W2084797045 @default.
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- W2571984714 doi "https://doi.org/10.1038/srep41009" @default.
- W2571984714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5382890" @default.
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- W2571984714 hasPublicationYear "2017" @default.
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