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- W2572220801 abstract "Abstract Astronauts have been previously shown to exhibit decreased salivary lysozyme and increased dental calculus and gingival inflammation in response to space flight, host factors that could contribute to oral diseases such as caries and periodontitis. However, the specific physiological response of caries-causing bacteria such as Streptococcus mutans to space flight and/or ground-based simulated microgravity has not been extensively investigated. In this study, high aspect ratio vessel S. mutans simulated microgravity and normal gravity cultures were assessed for changes in metabolite and transcriptome profiles, H 2 O 2 resistance, and competence in sucrose-containing biofilm media. Stationary phase S. mutans simulated microgravity cultures displayed increased killing by H 2 O 2 compared to normal gravity control cultures, but competence was not affected. RNA-seq analysis revealed that expression of 153 genes was up-regulated ≥2-fold and 94 genes down-regulated ≥2-fold during simulated microgravity high aspect ratio vessel growth. These included a number of genes located on extrachromosomal elements, as well as genes involved in carbohydrate metabolism, translation, and stress responses. Collectively, these results suggest that growth under microgravity analog conditions promotes changes in S. mutans gene expression and physiology that may translate to an altered cariogenic potential of this organism during space flight missions." @default.
- W2572220801 created "2017-01-26" @default.
- W2572220801 creator A5020751901 @default.
- W2572220801 creator A5049789683 @default.
- W2572220801 creator A5071848882 @default.
- W2572220801 date "2017-01-12" @default.
- W2572220801 modified "2023-10-06" @default.
- W2572220801 title "Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression" @default.
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- W2572220801 doi "https://doi.org/10.1038/s41526-016-0006-4" @default.
- W2572220801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5460135" @default.
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