FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W257239145> ?p ?o ?g. }

• W257239145 endingPage "63" @default.
• W257239145 startingPage "58" @default.
• W257239145 abstract "Aim: To determine frequency of tumors with immunohistochemical markers of cancer stem cells (CSC) CD44+/CD24− in patients with breast cancer (BC) of different molecular subtype and to evaluate their prognostic value. Object: Surgical material of 132 patients with BC stage I–II, age from 23 to 75 years, mean age — 50.2 ± 3.1 years was studied. Methods: Clinical, immunohistochemical (expression CD44+/CD24−), morphological, statistical. Results: BC is characterized by heterogeneity of molecular subtypes and expression of markers (CD44+/CD24−). Immunohistochemical study of expression of CSC markers in surgical material has detected their expression in 34 (25.4%) patients with BC of different molecular subtypes. The highest frequency of cells with expression of CSC marker was observed in patients with basal molecular subtype (44.8% patients). Most of BC patients with phenotype CD44+/CD24 had stage I of tumor process (34.3%). Statistical processing of data has showen that Yule colligation coefficient equaled 0.28 (р > 0.05) that argues poor correlation between stage of tumor process and number of tumors with positive expression of CSC markers. Statistical processing of data has showen high correlation between presence of cells with expression of CSC markers and metastases of BC in regional lymph nodes (Yule colligation coefficient equals 0.943; р < 0.5). Difference in overall survival of patients with BC of basal molecular subtype depending on expression of CSC CD44+/CD24− markers was detected. Survival of patients with basal BC was reliably higher at lack in tumors of cells with CSC markers CD44+/CD24− and, correspondingly, lower at presence of such cells (р < 0.05). In patients with BC of luminal (A and B), HER-2-positive subtypes, significant change in survival of patients depending on expression of CSC markers was not determined (р > 0.05). Conclusion: Significance of tumor cells with markers CD44+/CD24− within the limits of molecular subtype of BC may be additional criterion for advanced biological characteristic of BC, and in patients with BC of basal molecular subtype — for predictive evaluation of individual potential of tumor to aggressive clinical course." @default.
• W257239145 created "2016-06-24" @default.
• W257239145 creator A5016384709 @default.
• W257239145 creator A5021234370 @default.
• W257239145 creator A5024887204 @default.
• W257239145 creator A5029013285 @default.
• W257239145 creator A5037795322 @default.
• W257239145 creator A5083364404 @default.
• W257239145 date "2015-03-22" @default.
• W257239145 modified "2023-09-23" @default.
• W257239145 title "СD44+/CD24− MARKERS OF CANCER STEM CELLS IN PATIENTS WITH BREAST CANCER OF DIFFERENT MOLECULAR SUBTYPES" @default.
• W257239145 cites W1979333273 @default.
• W257239145 cites W1984850374 @default.
• W257239145 cites W1995280056 @default.
• W257239145 cites W2004878973 @default.
• W257239145 cites W2023826235 @default.
• W257239145 cites W2031770999 @default.
• W257239145 cites W2058569154 @default.
• W257239145 cites W2058865073 @default.
• W257239145 cites W2060185596 @default.
• W257239145 cites W2062791532 @default.
• W257239145 cites W2065189016 @default.
• W257239145 cites W2067256262 @default.
• W257239145 cites W2080138326 @default.
• W257239145 cites W2089001865 @default.
• W257239145 cites W2091242368 @default.
• W257239145 cites W2094639073 @default.
• W257239145 cites W2102741362 @default.
• W257239145 cites W2106292881 @default.
• W257239145 cites W2111942099 @default.
• W257239145 cites W2113633750 @default.
• W257239145 cites W2123562597 @default.
• W257239145 cites W2131994307 @default.
• W257239145 cites W2140987848 @default.
• W257239145 cites W2143995836 @default.
• W257239145 cites W2150575159 @default.
• W257239145 cites W2155390148 @default.
• W257239145 cites W2163292580 @default.
• W257239145 cites W2347195508 @default.
• W257239145 cites W2417586540 @default.
• W257239145 cites W2916115513 @default.
• W257239145 cites W2036576467 @default.
• W257239145 doi "https://doi.org/10.31768/2312-8852.2015.37(1):58-63" @default.
• W257239145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25804234" @default.
• W257239145 hasPublicationYear "2015" @default.
• W257239145 type Work @default.
• W257239145 sameAs 257239145 @default.
• W257239145 citedByCount "26" @default.
• W257239145 countsByYear W2572391452015 @default.
• W257239145 countsByYear W2572391452016 @default.
• W257239145 countsByYear W2572391452017 @default.
• W257239145 countsByYear W2572391452018 @default.
• W257239145 countsByYear W2572391452019 @default.
• W257239145 countsByYear W2572391452020 @default.
• W257239145 countsByYear W2572391452021 @default.
• W257239145 countsByYear W2572391452022 @default.
• W257239145 countsByYear W2572391452023 @default.
• W257239145 crossrefType "journal-article" @default.
• W257239145 hasAuthorship W257239145A5016384709 @default.
• W257239145 hasAuthorship W257239145A5021234370 @default.
• W257239145 hasAuthorship W257239145A5024887204 @default.
• W257239145 hasAuthorship W257239145A5029013285 @default.
• W257239145 hasAuthorship W257239145A5037795322 @default.
• W257239145 hasAuthorship W257239145A5083364404 @default.
• W257239145 hasBestOaLocation W2572391452 @default.
• W257239145 hasConcept C121608353 @default.
• W257239145 hasConcept C126322002 @default.
• W257239145 hasConcept C142724271 @default.
• W257239145 hasConcept C143998085 @default.
• W257239145 hasConcept C146357865 @default.
• W257239145 hasConcept C151730666 @default.
• W257239145 hasConcept C202751555 @default.
• W257239145 hasConcept C204232928 @default.
• W257239145 hasConcept C2778024521 @default.
• W257239145 hasConcept C2779306644 @default.
• W257239145 hasConcept C2779492189 @default.
• W257239145 hasConcept C2780932548 @default.
• W257239145 hasConcept C502942594 @default.
• W257239145 hasConcept C530470458 @default.
• W257239145 hasConcept C54355233 @default.
• W257239145 hasConcept C55427017 @default.
• W257239145 hasConcept C71924100 @default.
• W257239145 hasConcept C86803240 @default.
• W257239145 hasConceptScore W257239145C121608353 @default.
• W257239145 hasConceptScore W257239145C126322002 @default.
• W257239145 hasConceptScore W257239145C142724271 @default.
• W257239145 hasConceptScore W257239145C143998085 @default.
• W257239145 hasConceptScore W257239145C146357865 @default.
• W257239145 hasConceptScore W257239145C151730666 @default.
• W257239145 hasConceptScore W257239145C202751555 @default.
• W257239145 hasConceptScore W257239145C204232928 @default.
• W257239145 hasConceptScore W257239145C2778024521 @default.
• W257239145 hasConceptScore W257239145C2779306644 @default.
• W257239145 hasConceptScore W257239145C2779492189 @default.
• W257239145 hasConceptScore W257239145C2780932548 @default.
• W257239145 hasConceptScore W257239145C502942594 @default.
• W257239145 hasConceptScore W257239145C530470458 @default.
• W257239145 hasConceptScore W257239145C54355233 @default.

• next