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- W2572425284 abstract "Abstract Background The interleukin‐17 (IL‐17) cytokine pathway plays a key role in the development of psoriasis. Antibodies targeting IL‐17 or blocking its receptor may be a new therapeutic approach for psoriasis. To assist treatment selection in daily practice, it is essential to understand the benefit and risk profile of IL‐17 antagonists. Objective We performed a meta‐analysis to evaluate the efficacy and safety of IL‐17 antagonists in patients with psoriasis. Methods We searched a number of databases for relevant randomized controlled trials (RCTs) published before May 2016. The following outcomes were evaluated: Psoriasis Area and Severity Index (PASI) 75, 90, 100 response, Investigator's Global Assessment (IGA) score of 0 or 1 response, adverse events (AEs) and withdrawals. The meta‐analysis was performed using Review Manager 5.2 software. Results Nine RCTs with 5951 patients were included. IL‐17 antagonists achieved higher PASI 75, 90, 100 response rates and Dermatology Life Quality Index 0 or 1 response rates than placebo and a lower incidence of discontinuations due to lack of efficacy. In the safety analysis, no significant differences were found between the IL‐17 antagonists and placebo in the proportion of patients with serious AEs, cardiovascular disease and discontinuations due to AEs. However, IL‐17 antagonists were associated with a higher proportion of patients with any AEs and infections than placebo. Conclusion IL‐17 antagonists were effective, with an acceptable safety profile, for patients with plaque psoriasis. Vigilance because of the potential for infection will be necessary for IL‐17 antagonists." @default.
- W2572425284 created "2017-01-26" @default.
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- W2572425284 date "2017-02-08" @default.
- W2572425284 modified "2023-09-26" @default.
- W2572425284 title "Efficacy and safety of interleukin-17 antagonists in patients with plaque psoriasis: a meta-analysis from phase 3 randomized controlled trials" @default.
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- W2572425284 doi "https://doi.org/10.1111/jdv.14125" @default.
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