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- W2572437049 abstract "Treatment options for medically refractory epilepsy mainly include brain surgery, but electrical brain stimulation might be an option when surgery is not feasible or has already failed. Early experience with open-loop stimulation, i.e., either continual or scheduled stimulation, has shown effectiveness in seizure control. This mode of stimulation however is inefficient, nonspecific, and might lead to adverse effects such as depression. In contrast, stimulation delivered in response to specific electrophysiologic triggers is effective in seizure control, efficient, and delivers less current density to the brain. Recently approved responsive neurostimulation has shown efficacy at reducing seizure frequency and severity and is now in clinical use. Emerging methods of seizure detection contribute to establishing feedback loops that can trigger interventions that reduce cerebral excitability and ultimately achieve more effective seizure control for this subset of patients with epilepsy." @default.
- W2572437049 created "2017-01-26" @default.
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- W2572437049 date "2017-01-01" @default.
- W2572437049 modified "2023-10-16" @default.
- W2572437049 title "Feedback-Sensitive and Closed-Loop Solutions" @default.
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- W2572437049 doi "https://doi.org/10.1016/b978-0-12-800454-8.00002-1" @default.
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