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- W2572510840 abstract "This editorial refers to ‘Risk factors for excess mortality in adults with congenital heart diseases’, by J.M. Oliver et al . doi: 10.1093/eurheartj/ehw590. Oliver et al . have conducted a survival analysis of >3000 patients using prospective data from the local database of a large adult congenital heart disease (ACHD) unit in Madrid (Spain).1 The results were cross-checked with the Spanish National Death Index in order to calculate the standardized mortality ratio (SMR).There are two fascinating findings in the study of Oliver et al . First, there is a significant overlap in death rate across subgroups based on anatomical complexity of the underlying congenital heart defect; and, secondly, the authors were able to demonstrate that in the absence of additional risk factors, independent of the underlying anatomical complexity, ACHD survival did not differ from that of the reference population.The annual death rate for the entire cohort was 0.89% and the SMR was 2.64 [95% confidence interval (CI) 2.3–3.0], which is very similar to a recent report from Diller et al . who reported an annual death rate of 0.72% and an SMR of 2.29 (95% CI 2.08–2.53) in their patient cohort.2Although SMRs increased with increasing complexity of the underlying congenital heart defect and annual death rate was higher in patients with complex congenital heart disease (2.04%), mortality rates did not differ between simple and moderate complex congenital heart defects (0.79% and 0.68%, respectively); this for a median follow-up time of 10.5 years and a median age at entry of 22.5 years.The authors categorized patients based on the three …" @default.
- W2572510840 created "2017-01-26" @default.
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- W2572510840 date "2017-01-10" @default.
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- W2572510840 title "Individual risk stratification in adult congenital heart disease: the way to go?" @default.
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- W2572510840 doi "https://doi.org/10.1093/eurheartj/ehw641" @default.
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