FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2572859078> ?p ?o ?g. }

• W2572859078 endingPage "1097" @default.
• W2572859078 startingPage "1089" @default.
• W2572859078 abstract "Aims Translocation renal cell carcinoma ( tRCC ) is a rare subtype of kidney tumour characterized by translocations involving the transcription factor TFE 3 or TFEB . tRCC was introduced into the World Health Organization classification in 2004, but much is still unknown about the natural history, clinicopathological features and outcomes of the disease. The aim of this study was to describe the landscape of fusion transcript in a large single‐institution series of fluorescence in‐situ hybridization ( FISH )‐confirmed tRCC s and then to compare it to morphological and clinical data. Methods and results Paired‐end RNA sequencing was performed within a prospective database of the Department of Pathology, Centre Hospitalier Régional Universitaire (Lille, France). The diagnosis of tRCC was confirmed by FISH . Among a total of 1130 identified renal cell carcinomas, 21 cases (1.9%) showed rearrangement of the TFE 3 ( n = 20) or ( TFEB ) ( n = 1) gene. Median patient age was 31 years (range = 15–47), and the female‐to‐male ratio was 6:1. Five different TFE 3 fusion transcripts were identified; the most frequent TFE 3 partners were PRCC ( n = 4) and SFPQ ( n = 4). The other partners involved were ASPCR 1 ( n = 1) and MED 15 ( n = 1) genes as well as a novel TFE 3 partner, GRIPAP 1 . Conclusions We identified a new fusion partner, GRIPAP 1 . The prognostic role of transcript type could not be determined because our number of cases was too small. Four patients (19%) died of the disease, all of which presented with a lymph node involvement at diagnosis. We confirm that tRCC can be an aggressive tumour, especially those of advanced clinical stage." @default.
• W2572859078 created "2017-01-26" @default.
• W2572859078 creator A5023980322 @default.
• W2572859078 creator A5032005688 @default.
• W2572859078 creator A5032650752 @default.
• W2572859078 creator A5038024902 @default.
• W2572859078 creator A5042868812 @default.
• W2572859078 creator A5044622369 @default.
• W2572859078 creator A5055874787 @default.
• W2572859078 creator A5058115259 @default.
• W2572859078 creator A5058330133 @default.
• W2572859078 creator A5063935752 @default.
• W2572859078 creator A5064378838 @default.
• W2572859078 creator A5072226386 @default.
• W2572859078 creator A5076472816 @default.
• W2572859078 creator A5078203700 @default.
• W2572859078 date "2017-03-21" @default.
• W2572859078 modified "2023-10-05" @default.
• W2572859078 title "Incidence, clinicopathological features and fusion transcript landscape of translocation renal cell carcinomas" @default.
• W2572859078 cites W1530100936 @default.
• W2572859078 cites W1537837390 @default.
• W2572859078 cites W1544512474 @default.
• W2572859078 cites W1560626543 @default.
• W2572859078 cites W1583020265 @default.
• W2572859078 cites W1971358860 @default.
• W2572859078 cites W1972747987 @default.
• W2572859078 cites W1972752359 @default.
• W2572859078 cites W1987342480 @default.
• W2572859078 cites W1999670380 @default.
• W2572859078 cites W2001664031 @default.
• W2572859078 cites W2002583936 @default.
• W2572859078 cites W2004511237 @default.
• W2572859078 cites W2007481019 @default.
• W2572859078 cites W2016972161 @default.
• W2572859078 cites W2035855473 @default.
• W2572859078 cites W2044165483 @default.
• W2572859078 cites W2051455912 @default.
• W2572859078 cites W2055726418 @default.
• W2572859078 cites W2067955038 @default.
• W2572859078 cites W2068507286 @default.
• W2572859078 cites W2072997207 @default.
• W2572859078 cites W2073276354 @default.
• W2572859078 cites W2081188316 @default.
• W2572859078 cites W2082420723 @default.
• W2572859078 cites W2082764672 @default.
• W2572859078 cites W2091941055 @default.
• W2572859078 cites W2097094046 @default.
• W2572859078 cites W2106378598 @default.
• W2572859078 cites W2110405319 @default.
• W2572859078 cites W2111867681 @default.
• W2572859078 cites W2133908084 @default.
• W2572859078 cites W2135269189 @default.
• W2572859078 cites W2147712199 @default.
• W2572859078 cites W2155125484 @default.
• W2572859078 cites W2160342304 @default.
• W2572859078 cites W2160489513 @default.
• W2572859078 cites W2171112052 @default.
• W2572859078 cites W2173645581 @default.
• W2572859078 cites W2297190827 @default.
• W2572859078 cites W2309912032 @default.
• W2572859078 cites W2330018939 @default.
• W2572859078 cites W2335012284 @default.
• W2572859078 doi "https://doi.org/10.1111/his.13167" @default.
• W2572859078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28640961" @default.
• W2572859078 hasPublicationYear "2017" @default.
• W2572859078 type Work @default.
• W2572859078 sameAs 2572859078 @default.
• W2572859078 citedByCount "61" @default.
• W2572859078 countsByYear W25728590782017 @default.
• W2572859078 countsByYear W25728590782018 @default.
• W2572859078 countsByYear W25728590782019 @default.
• W2572859078 countsByYear W25728590782020 @default.
• W2572859078 countsByYear W25728590782021 @default.
• W2572859078 countsByYear W25728590782022 @default.
• W2572859078 countsByYear W25728590782023 @default.
• W2572859078 crossrefType "journal-article" @default.
• W2572859078 hasAuthorship W2572859078A5023980322 @default.
• W2572859078 hasAuthorship W2572859078A5032005688 @default.
• W2572859078 hasAuthorship W2572859078A5032650752 @default.
• W2572859078 hasAuthorship W2572859078A5038024902 @default.
• W2572859078 hasAuthorship W2572859078A5042868812 @default.
• W2572859078 hasAuthorship W2572859078A5044622369 @default.
• W2572859078 hasAuthorship W2572859078A5055874787 @default.
• W2572859078 hasAuthorship W2572859078A5058115259 @default.
• W2572859078 hasAuthorship W2572859078A5058330133 @default.
• W2572859078 hasAuthorship W2572859078A5063935752 @default.
• W2572859078 hasAuthorship W2572859078A5064378838 @default.
• W2572859078 hasAuthorship W2572859078A5072226386 @default.
• W2572859078 hasAuthorship W2572859078A5076472816 @default.
• W2572859078 hasAuthorship W2572859078A5078203700 @default.
• W2572859078 hasConcept C104317684 @default.
• W2572859078 hasConcept C111829193 @default.
• W2572859078 hasConcept C132647116 @default.
• W2572859078 hasConcept C138626823 @default.
• W2572859078 hasConcept C142724271 @default.
• W2572859078 hasConcept C2777472916 @default.
• W2572859078 hasConcept C2777542201 @default.
• W2572859078 hasConcept C2780849966 @default.

• next