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• W2572887968 abstract "The actin and intermediate filament cytoskeleltons contribute to numerous cellular processes, including morphogenesis, cytokinesis, and migration. These two cytoskeletal systems associate with each other, but the underlying mechanisms are incompletely understood. Here,we show that inactivation of vimentin leads to increased actin stress fiber assembly and contractility, and consequent elevation of myosin light chain phosphorylation and stabilization of tropomyosin-4.2. The vimentin knockout phenotypes can be rescued by re-expression of wild-type vimentin, but not by the non-filamentous ‘unit length form’ vimentin, demonstrating that intact vimentin intermediate filaments are required to facilitate the effects on the actin cytoskeleton. Finally, we provide evidence that the effects of vimentin on stress fibers are mediated by activation of RhoA through its guanine nucleotide exchange factor GEF-H1. Vimentin depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly. Taken together, these data reveal a new mechanism by which intermediate filaments regulate contractile actomyosin bundles, and may explain why elevated vimentin expression levels correlate with increased migration and invasion of cancer cells." @default.
• W2572887968 created "2017-01-26" @default.
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• W2572887968 date "2017-01-01" @default.
• W2572887968 modified "2023-10-05" @default.
• W2572887968 title "Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA" @default.
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• W2572887968 doi "https://doi.org/10.1242/jcs.196881" @default.
• W2572887968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5358333" @default.
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