FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2572904125> ?p ?o ?g. }

• W2572904125 endingPage "14592" @default.
• W2572904125 startingPage "14576" @default.
• W2572904125 abstract "// Zheng Chen 1, 6, * , Minghui Niu 1, * , Min Sun 1, * , Qingqing Yuan 1, * , Chencheng Yao 1 , Jingmei Hou 1 , Hong Wang 1 , Liping Wen 1 , Hongyong Fu 1 , Fan Zhou 1 , Zheng Li 2 , Zuping He 1, 3, 4, 5 1 State Key Laboratory of Oncogenes and Related Genes, Renji- Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 2 Department of Andrology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China 3 Shanghai Institute of Andrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China 4 Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China 5 Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China 6 Department of General Surgery, Suqian people's Hospital, The Affiliated Hospital of Xuzhou Medical University, Jiangsu 223800, China * These authors contributed equally to this work Correspondence to: Zuping He, email: zupinghe@sjtu.edu.cn Keywords: human, spermatogonial stem cells, transplantation, in vivo, transdifferentiation Received: November 25, 2016      Accepted: January 11, 2017      Published: January 18, 2017 ABSTRACT Here we proposed a new concept that human spermatogonial stem cells (SSCs) can transdifferentiate into hepatocytes in vivo . We first established liver injury model of mice by carbon tetrachloride to provide proper environment for human SSC transplantation. Liver mesenchymal cells were isolated from mice and identified phenotypically. Human SSC line was recombined with liver mesenchymal cells, and they were transplanted under renal capsules of nude mice with liver injury. The grafts expressed hepatocyte hallmarks, including ALB, AAT, CK18, and CYP1A2, whereas germ cell and SSC markers VASA and GPR125 were undetected in these cells, implicating that human SSCs were converted to hepatocytes. Furthermore, Western blots revealed high levels of PCNA, AFP, and ALB, indicating that human SSCs-derived hepatocytes had strong proliferation potential and features of hepatocytes. In addition, ALB–, CK8–, and CYP1A2– positive cells were detected in liver tissues of recipient mice. Significantly, no obvious lesion or teratomas was observed in several important organs and tissues of recipient mice, reflecting that transplantation of human SSCs was safe and feasible. Collectively, we have for the first time demonstrated that human SSCs can be transdifferentiated to hepatocyte in vivo . This study provides a novel approach for curing liver diseases using human SSC transplantation." @default.
• W2572904125 created "2017-01-26" @default.
• W2572904125 creator A5000748029 @default.
• W2572904125 creator A5014541123 @default.
• W2572904125 creator A5032769690 @default.
• W2572904125 creator A5033020983 @default.
• W2572904125 creator A5037674582 @default.
• W2572904125 creator A5049812561 @default.
• W2572904125 creator A5059164179 @default.
• W2572904125 creator A5060335470 @default.
• W2572904125 creator A5063507717 @default.
• W2572904125 creator A5064031029 @default.
• W2572904125 creator A5076735202 @default.
• W2572904125 creator A5081702138 @default.
• W2572904125 date "2017-01-18" @default.
• W2572904125 modified "2023-09-26" @default.
• W2572904125 title "Transdifferentiation of human male germline stem cells to hepatocytes <i>in vivo</i> via the transplantation under renal capsules" @default.
• W2572904125 cites W1551311666 @default.
• W2572904125 cites W1579368978 @default.
• W2572904125 cites W1957435946 @default.
• W2572904125 cites W1972488563 @default.
• W2572904125 cites W1976226574 @default.
• W2572904125 cites W1979686921 @default.
• W2572904125 cites W1982384048 @default.
• W2572904125 cites W1986947784 @default.
• W2572904125 cites W1988627175 @default.
• W2572904125 cites W1990574061 @default.
• W2572904125 cites W1992365936 @default.
• W2572904125 cites W1999914688 @default.
• W2572904125 cites W2020755558 @default.
• W2572904125 cites W2027011084 @default.
• W2572904125 cites W2032537363 @default.
• W2572904125 cites W2034639280 @default.
• W2572904125 cites W2035788198 @default.
• W2572904125 cites W2041911908 @default.
• W2572904125 cites W2053820570 @default.
• W2572904125 cites W2063746472 @default.
• W2572904125 cites W2065927663 @default.
• W2572904125 cites W2068511028 @default.
• W2572904125 cites W2074109780 @default.
• W2572904125 cites W2084575252 @default.
• W2572904125 cites W2090497735 @default.
• W2572904125 cites W2091443952 @default.
• W2572904125 cites W2096252347 @default.
• W2572904125 cites W2105782901 @default.
• W2572904125 cites W2107779263 @default.
• W2572904125 cites W2111354766 @default.
• W2572904125 cites W2112340954 @default.
• W2572904125 cites W2125881943 @default.
• W2572904125 cites W2128786355 @default.
• W2572904125 cites W2148247271 @default.
• W2572904125 cites W2150248371 @default.
• W2572904125 cites W2173755462 @default.
• W2572904125 cites W2274327856 @default.
• W2572904125 cites W2394820832 @default.
• W2572904125 cites W2517748498 @default.
• W2572904125 doi "https://doi.org/10.18632/oncotarget.14713" @default.
• W2572904125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5362427" @default.
• W2572904125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28107194" @default.
• W2572904125 hasPublicationYear "2017" @default.
• W2572904125 type Work @default.
• W2572904125 sameAs 2572904125 @default.
• W2572904125 citedByCount "14" @default.
• W2572904125 countsByYear W25729041252018 @default.
• W2572904125 countsByYear W25729041252019 @default.
• W2572904125 countsByYear W25729041252020 @default.
• W2572904125 countsByYear W25729041252021 @default.
• W2572904125 countsByYear W25729041252022 @default.
• W2572904125 countsByYear W25729041252023 @default.
• W2572904125 crossrefType "journal-article" @default.
• W2572904125 hasAuthorship W2572904125A5000748029 @default.
• W2572904125 hasAuthorship W2572904125A5014541123 @default.
• W2572904125 hasAuthorship W2572904125A5032769690 @default.
• W2572904125 hasAuthorship W2572904125A5033020983 @default.
• W2572904125 hasAuthorship W2572904125A5037674582 @default.
• W2572904125 hasAuthorship W2572904125A5049812561 @default.
• W2572904125 hasAuthorship W2572904125A5059164179 @default.
• W2572904125 hasAuthorship W2572904125A5060335470 @default.
• W2572904125 hasAuthorship W2572904125A5063507717 @default.
• W2572904125 hasAuthorship W2572904125A5064031029 @default.
• W2572904125 hasAuthorship W2572904125A5076735202 @default.
• W2572904125 hasAuthorship W2572904125A5081702138 @default.
• W2572904125 hasBestOaLocation W25729041251 @default.
• W2572904125 hasConcept C126322002 @default.
• W2572904125 hasConcept C16685009 @default.
• W2572904125 hasConcept C17744445 @default.
• W2572904125 hasConcept C191935318 @default.
• W2572904125 hasConcept C199539241 @default.
• W2572904125 hasConcept C207001950 @default.
• W2572904125 hasConcept C28328180 @default.
• W2572904125 hasConcept C2911091166 @default.
• W2572904125 hasConcept C54355233 @default.
• W2572904125 hasConcept C556039675 @default.
• W2572904125 hasConcept C60870556 @default.
• W2572904125 hasConcept C71924100 @default.
• W2572904125 hasConcept C86803240 @default.
• W2572904125 hasConceptScore W2572904125C126322002 @default.
• W2572904125 hasConceptScore W2572904125C16685009 @default.

• next