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- W2572974355 abstract "Cholestatic liver disease results from insufficient bile synthesis, secretion and/or flow through the biliary tract. Common presenting features include fatigue, pruritus, and cholestatic liver enzyme abnormalities wherein elevations of serum alkaline phosphatase and gamma-glutamyltransferases levels exceed those of alanine and aspartate aminotransferases. With prolonged cholestasis, fat soluble vitamin deficiencies, fibrosis, cirrhosis, and, on occasion, carcinoma of the biliary tract or liver can occur. Once mechanical obstruction to bile flow has been ruled out, the majority of causes can be classified as immune-mediated, infectious, or miscellaneous. Because specific therapeutic options are increasing for many causes of cholestasis, an accurate diagnosis is an important first step towards treatment. Thus, this review focuses on the diagnostic features of non-mechanical causes of cholestasis." @default.
- W2572974355 created "2017-01-26" @default.
- W2572974355 creator A5019987502 @default.
- W2572974355 creator A5035654219 @default.
- W2572974355 date "2017-06-22" @default.
- W2572974355 modified "2023-09-26" @default.
- W2572974355 title "Diagnostic considerations for cholestatic liver disease" @default.
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- W2572974355 doi "https://doi.org/10.1111/jgh.13738" @default.
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