Matches in SemOpenAlex for { <https://semopenalex.org/work/W2572985410> ?p ?o ?g. }
- W2572985410 abstract "This study investigated the effects of chronic homocysteine administration on some parameters of inflammation, such as cytokines (TNF-a, IL-1b and IL-6), chemokine CCL2 (MCP-1), nitrite and prostaglandin E2 levels, as well as on immunocontent of NF-jB/p65 subunit in hippocampus and/or serum of rats. Since acetylcholin- esterase has been associated with inflammation, we also evaluated the effect of homocysteine on this enzyme activity in hippocampus of rats. Wistar rats received daily subcutaneous injections of homocysteine (0.3-0.6 lmol/g body weight) or saline (control) from the 6th to the 28th days-of-age. One or 12 h after the last injection, rats were euthanized and hippocampus and serum were used. Results showed that chronic hyperhomocysteinemia significantly increased pro-inflammatory cytokines (TNF-a, IL-1b and IL-6), chemokine CCL2 (MCP-1) and prostaglandin E2 in hippocampus and serum of rats at 1 and 12 h after the last injection of homocysteine. Nitrite levels increased in hip- pocampus, but decreased in serum at 1 h after chronic hyperhomocysteinemia. Acetylcholinesterase activity and immunocontent of citoplasmic and nuclear NF-jB/p65 subunit were increased in hippocampus of rats subjected to hyperhomocysteinemia at 1 h, but did not alter at 12 h after the last injection of homocysteine. According to our results, chronic hyperhomocysteinemia increases inflam- matory parameters, suggesting that this process might be associated, at least in part, with the cerebrovascular and vascular dysfunctions characteristic of some homocys- tinuric patients." @default.
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- W2572985410 date "2012-01-01" @default.
- W2572985410 modified "2023-09-27" @default.
- W2572985410 title "Chronic Hyperhomocysteinemia Increases Inflammatory Markers in Hippocampus and Serum of Rats" @default.
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