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- W2573021522 abstract "Introduction Congenital heart malformations are risk factors that make children susceptible to infections resulting in inflammation. Material and methods The concentration of histamine as a modulator of inflammation was quantified in pericardial fluid and expression of histamine H4 receptor (H4R) and histaminereleasing factor (HRF) was determined at mRNA and protein levels. Samples of pericardium and pericardial fluid were obtained during cardiac reconstruction surgery in children. Results In children with pericarditis, increased levels of histamine were found and expression of H4R was localized on mast cells. Expression of HRF was independent of presence or absence of inflammation in pericardium and was localized within stationary epithelial cells. Conclusion Results indicate that involvement of H4R in pericardial inflammation depends on penetration of mast cells into inflamed tissue, but HRF may not be directly involved in inflammatory reaction of the pericardium." @default.
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- W2573021522 date "2010-01-01" @default.
- W2573021522 modified "2023-09-27" @default.
- W2573021522 title "Histamine in pericarditis of children with congenital heart" @default.
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