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- W2573103438 abstract "AN INCREASING proportion of patients with peptic ulcer due to gastrin-producing islet cell tumor are being recognized in whom features of the syndrome are atypical or delayed in onset.<sup>1-4</sup>In such instances, identifying the tumor and establishing its causal relationship with the ulcer<sup>2,4-6</sup>may involve complex surgical and biochemical methods.<sup>7,8</sup>The purpose of this paper is therefore to investigate the diagnostic importance of gastric secretory findings. Zollinger and Ellison<sup>9</sup>originally emphasized abnormally high nocturnal gastric secretion as characteristic of this syndrome, a finding confirmed by others.<sup>10</sup>Summerskill<sup>11</sup>found a greatly increased one-hour basal acid output which approximated unusually the acid response to an augmented dose of histamine. Rawson and co-workers<sup>12</sup>and Marks and associates<sup>13</sup>reported similar results, and Marks and colleagues proposed that the ratio of basal to maximal acid secretion would be useful in diagnosis of the syndrome.<sup>13</sup>Information included in many subsequent case" @default.
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- W2573103438 date "1966-05-01" @default.
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- W2573103438 title "Gastric Secretion With Ulcerogenic Islet Cell Tumor" @default.
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- W2573103438 doi "https://doi.org/10.1001/archinte.1966.03870110059012" @default.
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