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- W2573283701 abstract "Introduction: Numerous scientific reports indicate an increased risk of developing cardiovascular disease among patients with psoriasis vulgaris, which is related to, among others, elevated concentration of homocysteine and reduced concentration of folic acid. The long-term effect of biological therapy on the concentration of these substances has not been previously studied. The aim of this study was to evaluate the homocysteine and folic acid concentration in the sera of patients with psoriasis vulgaris under biological therapy (adalimumab, etanercept, infliximab, and ustekinumab). Material and methods: The study group consisted of 42 patients with psoriasis vulgaris treated with biologic therapy from 2008 to 2013 in the Department of Dermatology and Venereology, Medical University of Lodz. Blood samples were taken to determine the folic acid and homocysteine concentration before and at 12th, 52th, 104th and 156th weeks of treatment. The control group consisted of 20 healthy volunteers. The effectiveness of biological therapy was assessed on the basis of PASI. Results: There was a significant (p 0.05). Folate concentration in psoriatic patients’ sera was significantly lower than in healthy controls (respectively 5.12 vs 8.76 ng/ml, p 0.05). Conclusions: Reduced levels of folic acid, and slightly increased — homocysteine in the serum of patients with psoriasis may indicate that the dermatosis is one of the risk factors for atherosclerosis and cardiovascular. Studies involving larger groups of patients would clearly assess the impact of biological therapy on the level of homocysteine and folic acid, as well as the development of cardiovascular complications in psoriasis." @default.
- W2573283701 created "2017-01-26" @default.
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- W2573283701 date "2016-01-01" @default.
- W2573283701 modified "2023-09-23" @default.
- W2573283701 title "Wpływ terapii biologicznej na stężenie kwasu foliowego i homocysteiny w surowicy pacjentów z łuszczycą zwyczajną" @default.
- W2573283701 hasPublicationYear "2016" @default.
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