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- W2573435389 abstract "Significance The world’s population is growing older, and senescence of the immune system is a fundamental factor underlying morbidity and mortality. We report a direct molecular characterization of the effects of aging on the adaptive immune system by high-throughput sequencing of antibody transcripts in the peripheral blood of humans. Using a phylogenetic approach to quantify dissimilarity, we compared the immunoglobulin repertoires of young and elderly individuals at baseline and during a well-defined immunogenic perturbation in the form of influenza vaccination; we also studied the long-term effects of chronic infection. Our work reveals previously unappreciated signatures of immune senescence that may find diagnostic use and guide approaches for improving elderly patients’ antibody responses." @default.
- W2573435389 created "2017-01-26" @default.
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- W2573435389 date "2017-01-17" @default.
- W2573435389 modified "2023-10-17" @default.
- W2573435389 title "Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging" @default.
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- W2573435389 doi "https://doi.org/10.1073/pnas.1617959114" @default.
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