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- W2573485471 endingPage "1543" @default.
- W2573485471 startingPage "1532" @default.
- W2573485471 abstract "Complex gene regulation systems ensure the maintenance of cellular identity during early development in mammals. Eukaryotic small RNAs have emerged as critical players in RNA interference (RNAi) by mediating gene silencing during embryonic stem cell self-renewal. Most of the proteins involved in the biogenesis of small RNAs are essential for proliferation and differentiation into the three germ layers of mouse embryonic stem cells. In the last decade, new functions for some RNAi proteins, independent of their roles in RNAi pathways, have been demonstrated in different biological systems. In parallel, new concepts in stem cell biology have emerged. Here, we review and integrate the current understanding of how RNAi proteins regulate stem cell identity with the new advances in the stem cell field and the recent non-canonical functions of the RNAi proteins. Finally, we propose a reevaluation of all RNAi mutant phenotypes, as non-canonical (small non-coding RNA independent) functions may contribute to the molecular mechanisms governing mouse embryonic stem cells commitment." @default.
- W2573485471 created "2017-01-26" @default.
- W2573485471 creator A5031968337 @default.
- W2573485471 creator A5037598602 @default.
- W2573485471 creator A5042524541 @default.
- W2573485471 creator A5087401568 @default.
- W2573485471 date "2017-05-01" @default.
- W2573485471 modified "2023-10-16" @default.
- W2573485471 title "The Role of RNA Interference in Stem Cell Biology: Beyond the Mutant Phenotypes" @default.
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