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- W2573502857 abstract "Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Consequently, allergic patients have a defect in IFN-γ production. So far, however, all the experimental studies have investigated only the IFN-γ production induced by the causal allergen. The aim of this study is to investigate whether there is a difference in the in vitro IFN-γ production, using different allergens as stimuli, in patients presenting with rhinitis due to pollen allergy. Forty-one AR patients with pollen allergy were enrolled. IFN-γ-specific producing cells were stimulated with PHA, causal pollen, and House Dust Mite (HDM). IFN-γ production was assessed by cytokine ELISPOT. IFN-γ production of peripheral blood mononuclear cells (PBMC) stimulated by specific pollen was significantly lower than IFN-γ production of PBMC stimulated by HDM (p<0.001). IFN-γ production of PBMC stimulated by specific pollen was significantly lower than IFN-γ production of PBMC stimulated by PHA (p<0.001). Moreover, in the HDM-sensitized patients, there seems to be a trend for a different defect. The present study highlights that the defective IFN-γ production is allergen specific and that HDM sensitization may also affects this parameter." @default.
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- W2573502857 date "2008-05-01" @default.
- W2573502857 modified "2023-09-23" @default.
- W2573502857 title "Patients with Allergic Rhinitis Show an Allergen-Specific Interferon-Gamma Defect" @default.
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- W2573502857 doi "https://doi.org/10.1177/1721727x0800600206" @default.
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