FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2573510419> ?p ?o ?g. }

• W2573510419 endingPage "1393" @default.
• W2573510419 startingPage "1387" @default.
• W2573510419 abstract "Understanding the molecular processes characterizing Ewing sarcoma (EWS) cell migration is crucial to highlight novel therapies for patients with disseminated disease. In this study we analyzed the role of ROCK kinases in the regulation of cell migration, growth and differentiation of EWS cells. Overexpression of ROCK promotes invasion and metastasis in many solid tumors. However, the effect of ROCK in EWS has not been extensively investigated. Expression of ROCK1 and ROCK2 was analyzed by western blotting in a representative panel of human EWS cell lines, in comparison with the parameters of in vitro malignancy. We investigated the effects of a ROCK2 specific inhibitor toward those of a pan-ROCK inhibitor on the growth, migration and differentiation of two EWS cell lines. ROCK2 but not ROCK1 expression was found to be associated with in vitro cell migration and anchorage‑independent growth capabilities. Exposure of EWS cells to ROCK inhibitors significantly reduced migration and growth, while favoring morphology changes and neural differentiation. These effects were more striking when cells were specifically deprived of ROCK2 activity. Our findings lead to consider ROCK2, rather than ROCK1, as a possible molecular target for the treatment of EWS." @default.
• W2573510419 created "2017-01-26" @default.
• W2573510419 creator A5015636061 @default.
• W2573510419 creator A5017883233 @default.
• W2573510419 creator A5025533934 @default.
• W2573510419 creator A5044046662 @default.
• W2573510419 creator A5050080068 @default.
• W2573510419 creator A5083948167 @default.
• W2573510419 date "2017-01-20" @default.
• W2573510419 modified "2023-09-30" @default.
• W2573510419 title "Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy" @default.
• W2573510419 cites W1972507748 @default.
• W2573510419 cites W1982958028 @default.
• W2573510419 cites W1984975372 @default.
• W2573510419 cites W2017890252 @default.
• W2573510419 cites W2029681450 @default.
• W2573510419 cites W2032373323 @default.
• W2573510419 cites W2040430549 @default.
• W2573510419 cites W2058096164 @default.
• W2573510419 cites W2061058076 @default.
• W2573510419 cites W2061600983 @default.
• W2573510419 cites W2063656324 @default.
• W2573510419 cites W2064422567 @default.
• W2573510419 cites W2067019974 @default.
• W2573510419 cites W2083451010 @default.
• W2573510419 cites W2084504199 @default.
• W2573510419 cites W2093969600 @default.
• W2573510419 cites W2094962874 @default.
• W2573510419 cites W2100511287 @default.
• W2573510419 cites W2101515869 @default.
• W2573510419 cites W2115988398 @default.
• W2573510419 cites W2120439608 @default.
• W2573510419 cites W2128472785 @default.
• W2573510419 cites W2128665281 @default.
• W2573510419 cites W2144023435 @default.
• W2573510419 cites W2146337514 @default.
• W2573510419 cites W2148750784 @default.
• W2573510419 cites W2160175915 @default.
• W2573510419 cites W2165673443 @default.
• W2573510419 cites W2166288784 @default.
• W2573510419 cites W2167872282 @default.
• W2573510419 cites W2171365654 @default.
• W2573510419 cites W2293143569 @default.
• W2573510419 cites W257491497 @default.
• W2573510419 doi "https://doi.org/10.3892/or.2017.5397" @default.
• W2573510419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5364828" @default.
• W2573510419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28112365" @default.
• W2573510419 hasPublicationYear "2017" @default.
• W2573510419 type Work @default.
• W2573510419 sameAs 2573510419 @default.
• W2573510419 citedByCount "12" @default.
• W2573510419 countsByYear W25735104192017 @default.
• W2573510419 countsByYear W25735104192018 @default.
• W2573510419 countsByYear W25735104192020 @default.
• W2573510419 countsByYear W25735104192021 @default.
• W2573510419 countsByYear W25735104192022 @default.
• W2573510419 countsByYear W25735104192023 @default.
• W2573510419 crossrefType "journal-article" @default.
• W2573510419 hasAuthorship W2573510419A5015636061 @default.
• W2573510419 hasAuthorship W2573510419A5017883233 @default.
• W2573510419 hasAuthorship W2573510419A5025533934 @default.
• W2573510419 hasAuthorship W2573510419A5044046662 @default.
• W2573510419 hasAuthorship W2573510419A5050080068 @default.
• W2573510419 hasAuthorship W2573510419A5083948167 @default.
• W2573510419 hasBestOaLocation W25735104191 @default.
• W2573510419 hasConcept C121608353 @default.
• W2573510419 hasConcept C133717845 @default.
• W2573510419 hasConcept C1491633281 @default.
• W2573510419 hasConcept C184235292 @default.
• W2573510419 hasConcept C201800478 @default.
• W2573510419 hasConcept C2779013556 @default.
• W2573510419 hasConcept C2779331819 @default.
• W2573510419 hasConcept C2779399171 @default.
• W2573510419 hasConcept C2781018059 @default.
• W2573510419 hasConcept C29537977 @default.
• W2573510419 hasConcept C502942594 @default.
• W2573510419 hasConcept C54355233 @default.
• W2573510419 hasConcept C62112901 @default.
• W2573510419 hasConcept C86803240 @default.
• W2573510419 hasConcept C95444343 @default.
• W2573510419 hasConcept C97029542 @default.
• W2573510419 hasConceptScore W2573510419C121608353 @default.
• W2573510419 hasConceptScore W2573510419C133717845 @default.
• W2573510419 hasConceptScore W2573510419C1491633281 @default.
• W2573510419 hasConceptScore W2573510419C184235292 @default.
• W2573510419 hasConceptScore W2573510419C201800478 @default.
• W2573510419 hasConceptScore W2573510419C2779013556 @default.
• W2573510419 hasConceptScore W2573510419C2779331819 @default.
• W2573510419 hasConceptScore W2573510419C2779399171 @default.
• W2573510419 hasConceptScore W2573510419C2781018059 @default.
• W2573510419 hasConceptScore W2573510419C29537977 @default.
• W2573510419 hasConceptScore W2573510419C502942594 @default.
• W2573510419 hasConceptScore W2573510419C54355233 @default.
• W2573510419 hasConceptScore W2573510419C62112901 @default.
• W2573510419 hasConceptScore W2573510419C86803240 @default.
• W2573510419 hasConceptScore W2573510419C95444343 @default.
• W2573510419 hasConceptScore W2573510419C97029542 @default.
• W2573510419 hasIssue "3" @default.

• next