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• W2573683529 abstract "// Danielle Fernandes Durso 1, 2, * , Maria Giulia Bacalini 3, * , Ítalo Faria do Valle 4, 5 , Chiara Pirazzini 3 , Massimiliano Bonafé 1 , Gastone Castellani 5 , Ana Maria Caetano Faria 6 , Claudio Franceschi 1, 3, 7, * , Paolo Garagnani 1, 7, 8, * , Christine Nardini 9, * 1 Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, Bologna, Italy 2 National Counsel of Technological and Scientific Development (CNPq), ministry of science technology and innovation (MCTI), Brasilia, Brazil 3 IRCCS Institute of Neurological Sciences, Bologna, Italy 4 CAPES Foundation, Ministry of Education of Brazil–Brasília (DF), Brazil 5 Department of Physics and Astronomy, University of Bologna, Bologna, Italy 6 Biochemistry and Immunology Department, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil 7 Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy 8 Applied Biomedical Research Center, S. Orsola-Malpighi Polyclinic, Bologna, Italy 9 Personal Genomics S.r.l., Verona, Italy * These authors contributed equally to this work Correspondence to: Christine Nardini, email: christine.nardini.rsrc@gmail.com Paolo Garagnani, email: paolo.garagnani2@unibo.it Claudio Franceschi, email: claudio.franceschi@unibo.it Keywords: DNA methylation, colorectal cancer, differential analysis, network analysis, infinium human methylation 450 Received: June 08, 2016      Accepted: December 27, 2016      Published: January 10, 2017 ABSTRACT Colorectal cancer is among the leading causes of cancer death worldwide. Despite numerous molecular characterizations of the phenomenon, the exact dynamics of its onset and progression remain elusive. Colorectal cancer onset has been characterized by changes in DNA methylation profiles, that, owing to the stability of their patterns, are promising candidates to shed light on the molecular events laying at the base of this phenomenon. To exploit this stability and reinforce it, we conducted a meta-analysis on publicly available DNA methylation datasets generated on: normal colorectal, adenoma (ADE) and adenocarcinoma (CRC) samples using the Illumina 450k array, in the systems medicine frame, searching for tumor gene episignatures, to produce a carefully selected list of potential drivers, markers and targets of the disease. The analysis proceeds from a differential meta-analysis of the methylation profiles using an analytical pipeline recently developed by our group [ 1 ], through network reconstruction, topological and functional analyses, to finally highlight relevant epigenomic features. Our results show that genes already highlighted for their genetic or transcriptional alteration in colorectal cancer are also differentially methylated, reinforcing -regardless of the level of cellular control- their role in the complex of alterations involved in tumorigenesis. These findings were finally validated in an independent cohort from The Cancer Genome Atlas (TCGA)." @default.
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• W2573683529 date "2017-01-10" @default.
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• W2573683529 title "Aberrant methylation patterns in colorectal cancer: a meta-analysis" @default.
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• W2573683529 cites W1974047233 @default.
• W2573683529 cites W1974747095 @default.
• W2573683529 cites W1975224807 @default.
• W2573683529 cites W1994322947 @default.
• W2573683529 cites W1994473465 @default.
• W2573683529 cites W2003544873 @default.
• W2573683529 cites W2004448254 @default.
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• W2573683529 cites W2029197798 @default.
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• W2573683529 cites W2043621747 @default.
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• W2573683529 cites W2057158494 @default.
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• W2573683529 doi "https://doi.org/10.18632/oncotarget.14590" @default.
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