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• W2573763695 abstract "The study of the times and sequence of neuron formation in various structures of the mammalian brain has made substantial progress thanks to the use of autoradiographic techniques, by which the germinative precursors of neurons can be tagged with 3H-thymidine and the subsequent fate of the labeled cells can be followed [4]. It has been shown that in both the archic0rtex and the neocortex neurons are formed in an order which corresponds to the arrangement of the architectonic layers [6-9]. Meanwhile the results so far obtained have yielded no information on correlation between neurogenesis and the vertical (radial) organization of functional neuronal modules detectable in the neocortex in the form of minicolumns and macrocolumns, and in the hippocampus in the form of narrow radial segments [I, 2]. It has recently been suggested that the germinative zones of the embryonic brain are organized as loci, or discrete proliferative units, each of which produces neurons of single radial segments of screened brain structures [12, 13]. This hypothesis is based on data on migration of young neurons along fibers of the radial glia and on observations showing that neurogenesis takes place at different times in large segments (comparable with architectonic fields) in the neocortex, hippocampus, and lateral geniculate body [12-15]. Experimental Proof of the discrete character of neurogenesis, comparable in scale with the dimensions of single functional modules, was first obtained by the present writers in an investigation [5] the results of which demonstrated a mosaic pattern of alternation of groups of neurons differing in the intensity of labeling in the neocortex of day-old mice receiving 3H-thymidine during embryonic development. These data indicate asynchronous production of neurons supplied to the same layer of cortex by small groups of cells in the germinative zone, each of which may give rise to a single ontogenetic column in the course of embryogenesis, on the basis of which the functional minicolumn of the neocortex is considered to be formed [2]. The question naturally arises: How clearly defined is the mosaicism of neurogenesis in other brain structures and, in particular, in structures of screened type? The hippocampus, which has a clearly defined laminar structure, and in which radial modules have been discovered by physiological methods[l], is very interesting from this point of view. Data on the order and gradients of neurogenesis in the hippocampus are largely contradictory [6, 7, 14] and require further clarification. The aim of this investigation was to study the space and time sequence of neuron formation and to look for the presence of mosaicism of neurogenesis in area CA1 of Ammon's horn of the mouse hippocampus, one of the most regularly arranged hippocampal areas [i]." @default.
• W2573763695 created "2017-01-26" @default.
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• W2573763695 date "1986-01-01" @default.
• W2573763695 modified "2023-09-27" @default.
• W2573763695 title "KEY WOP~S: hippocampus; neurogenesis; 3H-thymidine; autoradiography." @default.
• W2573763695 hasPublicationYear "1986" @default.
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