FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2573769293> ?p ?o ?g. }

• W2573769293 abstract "Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility genes with PD, few of them were replicated and the pathogenesis of PD remains to be clarified. Epigenetics is considered to play an important role in etiology of complex traits and diseases, and DNA methylation is one of the major forms of epigenetic modifications. In this study, we performed an epigenome-wide association study of PD using DNA methylation arrays so as to investigate the possibility that different levels of DNA methylation might be associated with PD.The DNA methylation levels of CpG sites across the genome were examined with genomic DNA samples (PD, N = 48, control, N = 48) extracted from peripheral blood. Methylation arrays were used for the analysis. β values, which represent the levels of DNA methylation, were normalized via an appropriate pipeline. Then, β values were converted to M values via the logit transformation for epigenome-wide association study. The relationship between each DNA methylation site and PD was assessed by linear regression analysis with adjustments for the effects of leukocyte subsets.Forty CpG sites showed significant association with PD at 5% FDR correction, though the differences of the DNA methylation levels were relatively small. Most of the significant CpG sites (37/40 CpG sites) were located in or around CpG islands. Many of the significant CpG sites (27/40 CpG sites) were located upstream of genes, and all such CpG sites with the exception of two were hypomethylated in PD subjects. A pathway analysis on the genes annotated to the significant CpG sites identified several pathways, including positive regulation of lymphocyte activation.Although future studies with larger number of samples are necessary to confirm the small DNA methylation abnormalities associated with PD, there is a possibility that several CpG sites might be associated, together as a group, with PD." @default.
• W2573769293 created "2017-01-26" @default.
• W2573769293 creator A5000418168 @default.
• W2573769293 creator A5004615822 @default.
• W2573769293 creator A5023310771 @default.
• W2573769293 creator A5027714231 @default.
• W2573769293 creator A5032229122 @default.
• W2573769293 creator A5040367383 @default.
• W2573769293 creator A5042538453 @default.
• W2573769293 creator A5048571730 @default.
• W2573769293 creator A5052373411 @default.
• W2573769293 creator A5054769681 @default.
• W2573769293 creator A5070460587 @default.
• W2573769293 creator A5080615156 @default.
• W2573769293 creator A5082811265 @default.
• W2573769293 creator A5085717963 @default.
• W2573769293 date "2017-01-21" @default.
• W2573769293 modified "2023-10-17" @default.
• W2573769293 title "Epigenome-wide association study of DNA methylation in panic disorder" @default.
• W2573769293 cites W1480269362 @default.
• W2573769293 cites W1513975451 @default.
• W2573769293 cites W1516580926 @default.
• W2573769293 cites W1612719023 @default.
• W2573769293 cites W1918724965 @default.
• W2573769293 cites W1974047233 @default.
• W2573769293 cites W1975528145 @default.
• W2573769293 cites W1976787939 @default.
• W2573769293 cites W1984726732 @default.
• W2573769293 cites W1984967391 @default.
• W2573769293 cites W1985444222 @default.
• W2573769293 cites W1993478762 @default.
• W2573769293 cites W1994899118 @default.
• W2573769293 cites W1995961335 @default.
• W2573769293 cites W2009462177 @default.
• W2573769293 cites W2014852291 @default.
• W2573769293 cites W2015251162 @default.
• W2573769293 cites W2017502278 @default.
• W2573769293 cites W2021501413 @default.
• W2573769293 cites W2025242208 @default.
• W2573769293 cites W2029776070 @default.
• W2573769293 cites W2036320151 @default.
• W2573769293 cites W2037651349 @default.
• W2573769293 cites W2038296024 @default.
• W2573769293 cites W2042793550 @default.
• W2573769293 cites W2053102671 @default.
• W2573769293 cites W2055237453 @default.
• W2573769293 cites W2056040742 @default.
• W2573769293 cites W2066612090 @default.
• W2573769293 cites W2067055066 @default.
• W2573769293 cites W2069770612 @default.
• W2573769293 cites W2070396195 @default.
• W2573769293 cites W2076363539 @default.
• W2573769293 cites W2079956181 @default.
• W2573769293 cites W2083944290 @default.
• W2573769293 cites W2084286303 @default.
• W2573769293 cites W2100178612 @default.
• W2573769293 cites W2103017472 @default.
• W2573769293 cites W2103714979 @default.
• W2573769293 cites W2104323563 @default.
• W2573769293 cites W2105394148 @default.
• W2573769293 cites W2106608030 @default.
• W2573769293 cites W2107060225 @default.
• W2573769293 cites W2107665951 @default.
• W2573769293 cites W2117347068 @default.
• W2573769293 cites W2122230573 @default.
• W2573769293 cites W2123722482 @default.
• W2573769293 cites W2125477221 @default.
• W2573769293 cites W2127431419 @default.
• W2573769293 cites W2129141634 @default.
• W2573769293 cites W2130523009 @default.
• W2573769293 cites W2132823987 @default.
• W2573769293 cites W2142574959 @default.
• W2573769293 cites W2145732131 @default.
• W2573769293 cites W2149013996 @default.
• W2573769293 cites W2150127222 @default.
• W2573769293 cites W2161857374 @default.
• W2573769293 cites W2162086299 @default.
• W2573769293 cites W2165101781 @default.
• W2573769293 cites W2166968390 @default.
• W2573769293 cites W2169556367 @default.
• W2573769293 cites W2219701962 @default.
• W2573769293 cites W2219957567 @default.
• W2573769293 cites W2310743771 @default.
• W2573769293 cites W2317947758 @default.
• W2573769293 cites W2328700233 @default.
• W2573769293 cites W2417675162 @default.
• W2573769293 cites W2438467628 @default.
• W2573769293 cites W2523285199 @default.
• W2573769293 cites W3171418018 @default.
• W2573769293 doi "https://doi.org/10.1186/s13148-016-0307-1" @default.
• W2573769293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5270210" @default.
• W2573769293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28149334" @default.
• W2573769293 hasPublicationYear "2017" @default.
• W2573769293 type Work @default.
• W2573769293 sameAs 2573769293 @default.
• W2573769293 citedByCount "47" @default.
• W2573769293 countsByYear W25737692932017 @default.
• W2573769293 countsByYear W25737692932018 @default.
• W2573769293 countsByYear W25737692932019 @default.
• W2573769293 countsByYear W25737692932020 @default.

• next