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- W2573887189 startingPage "18" @default.
- W2573887189 abstract "Antibody-drug conjugates (ADCs), constructed with monoclonal antibodies (mAbs), linkers, and natural cytotoxins, are innovative drugs developed for oncotherapy. Owing to the distinctive advantages of both chemotherapy drugs and antibody drugs, ADCs have obtained enormous success during the past several years. The development of highly specific antibodies, novel marine toxins' applications, and innovative linker technologies all accelerate the rapid R&D of ADCs. Meanwhile, some challenges remain to be solved for future ADCs. For instance, varieties of site-specific conjugation have been proposed for solving the inhomogeneity of DARs (Drug Antibody Ratios). In this review, the usages of various natural toxins, especially marine cytotoxins, and the development strategies for ADCs in the past decade are summarized. Representative ADCs with marine cytotoxins in the pipeline are introduced and characterized with their new features, while perspective comments for future ADCs are proposed." @default.
- W2573887189 created "2017-01-26" @default.
- W2573887189 creator A5029847225 @default.
- W2573887189 creator A5038145110 @default.
- W2573887189 creator A5049595440 @default.
- W2573887189 creator A5083973997 @default.
- W2573887189 creator A5086154362 @default.
- W2573887189 creator A5086418698 @default.
- W2573887189 date "2017-01-13" @default.
- W2573887189 modified "2023-10-15" @default.
- W2573887189 title "Marine Antibody–Drug Conjugates: Design Strategies and Research Progress" @default.
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