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- W257392725 abstract "The c-myc proto-oncogene encodes a nuclear phosphoprotein which probably plays a crucial role in growth control [4]. The protein has DNA-binding activity in vitro, but its function remains unknown. While avian retroviruses carrying the closely related v-myc sequence rapidly transform myeloid cells, the cellular myc gene has been strongly implicated in several types of lymphoid neoplasia. The fundamental mechanism releasing the oncogenic potential of c-myc is believed to be deregulation of its expression. Most chicken bursal lymphomas resulting from infection with avian leukosis virus, which does not itself bear an oncogene, carry a provirus near or within the c-myc gene [6]. About a quarter of T lymphomas with a retroviral aetiology also bear a c-myc-associated provirus [3]." @default.
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- W257392725 date "1987-01-01" @default.
- W257392725 modified "2023-09-26" @default.
- W257392725 title "The myc Oncogene and Lymphoid Neoplasia: From Translocations to Transgenic Mice" @default.
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- W257392725 doi "https://doi.org/10.1007/978-3-642-72624-8_51" @default.
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