FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2574006066> ?p ?o ?g. }

• W2574006066 endingPage "694" @default.
• W2574006066 startingPage "691" @default.
• W2574006066 abstract "MA026 is an antiviral natural compound against hepatitis C virus (HCV). It was recently reported that MA026 binds claudin-1 (CLDN1) and inhibits HCV infection. Although CLDN1 is an important component of tight junctions (TJ) in the epithelial cell layer, the effects of MA026 on the TJ barrier function remained to be revealed. Here we report that MA026 irreversibly opens the TJ. MA026 irreversibly increased FD4 permeability and decreased transepithelial electrical resistance (TER) for at least 5 h. Although MA026 increased Ca2+ influx in layered MDCKII cells, the Ca2+ influx was less than that of capsaicin, a reversible TJ opener. Moreover, MA026 did not induce the dephosphorylation of cofilin and reorganization of F-actin structure. Although the mechanism is left to be disclosed, these results suggest that MA026 is a novel irreversible TJ opener probably by targeting CLDN1." @default.
• W2574006066 created "2017-01-26" @default.
• W2574006066 creator A5009893639 @default.
• W2574006066 creator A5014568645 @default.
• W2574006066 creator A5035657306 @default.
• W2574006066 creator A5036936109 @default.
• W2574006066 creator A5084345903 @default.
• W2574006066 creator A5084372797 @default.
• W2574006066 creator A5088109262 @default.
• W2574006066 date "2017-01-18" @default.
• W2574006066 modified "2023-09-27" @default.
• W2574006066 title "MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane" @default.
• W2574006066 cites W1554042779 @default.
• W2574006066 cites W1969897371 @default.
• W2574006066 cites W1993033152 @default.
• W2574006066 cites W2038204970 @default.
• W2574006066 cites W2045247602 @default.
• W2574006066 cites W2065062437 @default.
• W2574006066 cites W2075147482 @default.
• W2574006066 cites W2132024007 @default.
• W2574006066 cites W2408908640 @default.
• W2574006066 doi "https://doi.org/10.1038/ja.2016.168" @default.
• W2574006066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28096546" @default.
• W2574006066 hasPublicationYear "2017" @default.
• W2574006066 type Work @default.
• W2574006066 sameAs 2574006066 @default.
• W2574006066 citedByCount "5" @default.
• W2574006066 countsByYear W25740060662021 @default.
• W2574006066 countsByYear W25740060662022 @default.
• W2574006066 countsByYear W25740060662023 @default.
• W2574006066 crossrefType "journal-article" @default.
• W2574006066 hasAuthorship W2574006066A5009893639 @default.
• W2574006066 hasAuthorship W2574006066A5014568645 @default.
• W2574006066 hasAuthorship W2574006066A5035657306 @default.
• W2574006066 hasAuthorship W2574006066A5036936109 @default.
• W2574006066 hasAuthorship W2574006066A5084345903 @default.
• W2574006066 hasAuthorship W2574006066A5084372797 @default.
• W2574006066 hasAuthorship W2574006066A5088109262 @default.
• W2574006066 hasBestOaLocation W25740060661 @default.
• W2574006066 hasConcept C11960822 @default.
• W2574006066 hasConcept C12554922 @default.
• W2574006066 hasConcept C125705527 @default.
• W2574006066 hasConcept C142724271 @default.
• W2574006066 hasConcept C1491633281 @default.
• W2574006066 hasConcept C149402561 @default.
• W2574006066 hasConcept C159047783 @default.
• W2574006066 hasConcept C177779419 @default.
• W2574006066 hasConcept C178666793 @default.
• W2574006066 hasConcept C181912034 @default.
• W2574006066 hasConcept C185592680 @default.
• W2574006066 hasConcept C200082930 @default.
• W2574006066 hasConcept C201508349 @default.
• W2574006066 hasConcept C2522874641 @default.
• W2574006066 hasConcept C2775962179 @default.
• W2574006066 hasConcept C2776408679 @default.
• W2574006066 hasConcept C2779134260 @default.
• W2574006066 hasConcept C2779567548 @default.
• W2574006066 hasConcept C3008058167 @default.
• W2574006066 hasConcept C51872919 @default.
• W2574006066 hasConcept C51911345 @default.
• W2574006066 hasConcept C524204448 @default.
• W2574006066 hasConcept C54355233 @default.
• W2574006066 hasConcept C55493867 @default.
• W2574006066 hasConcept C71924100 @default.
• W2574006066 hasConcept C81885089 @default.
• W2574006066 hasConcept C86803240 @default.
• W2574006066 hasConcept C95444343 @default.
• W2574006066 hasConceptScore W2574006066C11960822 @default.
• W2574006066 hasConceptScore W2574006066C12554922 @default.
• W2574006066 hasConceptScore W2574006066C125705527 @default.
• W2574006066 hasConceptScore W2574006066C142724271 @default.
• W2574006066 hasConceptScore W2574006066C1491633281 @default.
• W2574006066 hasConceptScore W2574006066C149402561 @default.
• W2574006066 hasConceptScore W2574006066C159047783 @default.
• W2574006066 hasConceptScore W2574006066C177779419 @default.
• W2574006066 hasConceptScore W2574006066C178666793 @default.
• W2574006066 hasConceptScore W2574006066C181912034 @default.
• W2574006066 hasConceptScore W2574006066C185592680 @default.
• W2574006066 hasConceptScore W2574006066C200082930 @default.
• W2574006066 hasConceptScore W2574006066C201508349 @default.
• W2574006066 hasConceptScore W2574006066C2522874641 @default.
• W2574006066 hasConceptScore W2574006066C2775962179 @default.
• W2574006066 hasConceptScore W2574006066C2776408679 @default.
• W2574006066 hasConceptScore W2574006066C2779134260 @default.
• W2574006066 hasConceptScore W2574006066C2779567548 @default.
• W2574006066 hasConceptScore W2574006066C3008058167 @default.
• W2574006066 hasConceptScore W2574006066C51872919 @default.
• W2574006066 hasConceptScore W2574006066C51911345 @default.
• W2574006066 hasConceptScore W2574006066C524204448 @default.
• W2574006066 hasConceptScore W2574006066C54355233 @default.
• W2574006066 hasConceptScore W2574006066C55493867 @default.
• W2574006066 hasConceptScore W2574006066C71924100 @default.
• W2574006066 hasConceptScore W2574006066C81885089 @default.
• W2574006066 hasConceptScore W2574006066C86803240 @default.
• W2574006066 hasConceptScore W2574006066C95444343 @default.
• W2574006066 hasIssue "5" @default.
• W2574006066 hasLocation W25740060661 @default.
• W2574006066 hasLocation W25740060662 @default.

• next