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• W2574128581 abstract "The innate immune sensing of pathogens is important for host to mount defensive responses. STING has emerged in recent years as a critical signaling adaptor in the immune response to cytosolic DNA and RNA derived from pathogens. Liu et al. (2016) demonstrate that the RIG-I-dependent RNA sensing signaling induces STING expression via a TNF-α and IFN-α synergy. The up-regulation of STING is vital for 5'pppRNA restriction of HSV, a DNA virus that infects humans and causes herpes, in vitro and in vivo. This study provides new insights into the cross talk between DNA and RNA pathogen-sensing systems via the control of STING." @default.
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• W2574128581 date "2017-05-03" @default.
• W2574128581 modified "2023-09-25" @default.
• W2574128581 title "RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways" @default.
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• W2574128581 doi "https://doi.org/10.14800/ics.1491" @default.
• W2574128581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5298905" @default.
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