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• W2574204043 abstract "// Fuu-Jen Tsai 1, 2, 3, * , Tsung-Jung Ho 1, 4, 5, * , Chi-Fung Cheng 6 , Yi-Tzone Shiao 7 , Wen-Kuei Chien 8 , Jin-Hua Chen 8, 9 , Xiang Liu 10 , Hsinyi Tsang 10 , Ting-Hsu Lin 2 , Chiu-Chu Liao 2 , Shao-Mei Huang 2 , Ju-Pi Li 1, 11 , Cheng-Wen Lin 12 , Jaung-Geng Lin 1 , Yu-Ching Lan 13 , Yu-Huei Liu 2, 14 , Chien-Hui Hung 15 , Jung-Chun Lin 16 , Chih-Chien Lin 17 , Chih-Ho Lai 18 , Wen-Miin Liang 6 , Ying-Ju Lin 1, 2  1 School of Chinese Medicine, China Medical University, Taichung, Taiwan  2 Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan  3 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan  4 Division of Chinese Medicine, China Medical University Beigang Hospital, Yunlin County, Taiwan  5 Division of Chinese Medicine, Tainan Municipal An-Nan Hospital-China Medical University, Tainan, Taiwan  6 Graduate Institute of Biostatistics, School of Public Health, China Medical University, Taichung, Taiwan  7 Heart Center, China Medical University Hospital, Taichung, Taiwan  8 Biostatistics Center, College of Management, Taipei Medical University, Taipei, Taiwan  9 School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan 10 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 11 Rheumatism Research Center, China Medical University Hospital, Taichung, Taiwan 12 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan 13 Department of Health Risk Management, China Medical University, Taichung, Taiwan 14 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 15 Graduate Institute of Clinical Medical Science, Chang-Gung University, Taipei, Taiwan 16 School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 17 Department of Cosmetic Science, Providence University, Taichung, Taiwan 18 Department of Microbiology and Immunology, Chang Gung University, Taoyuan, Taiwan * These authors have contributed equally to this work Correspondence to: Ying-Ju Lin, email: yjlin.kath@gmail.com Wen-Miin Liang, email: wmliang@mail.cmu.edu.tw Keywords: type 2 diabetes, ischemic heart disease, Chinese herbal medicine, oxidative stress, cardiomyoblasts Received: June 01, 2016      Accepted: December 27, 2016      Published: January 14, 2017 ABSTRACT Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older ( P < .0001, log rank test) regardless of gender ( P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao-Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H 2 O 2 -exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3β and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D." @default.
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• W2574204043 date "2017-01-14" @default.
• W2574204043 modified "2023-10-17" @default.
• W2574204043 title "Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts" @default.
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