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- W2574252012 abstract "Abstract Long noncoding RNA s (lnc RNA s), a novel class of transcripts that have critical roles in carcinogenesis and progression, have emerged as important gene expression modulators. Recent evidence indicates that lnc RNA taurine‐upregulated gene 1 ( TUG 1) functions as an oncogene in numerous types of human cancers. However, its function in the development of cervical cancer remains unknown. The aim of this research was to investigate the clinical significance and biological functions of TUG 1 in cervical cancer. TUG 1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines by quantitative real‐time polymerase chain reaction ( qRT ‐ PCR ). Elevated TUG 1 expression was correlated with larger tumor size, advanced international federation of gynecology and obstetrics ( FIGO ) stage, poor differentiation, and lymph node metastasis. Furthermore, knockdown of TUG 1 suppressed cell proliferation with activation of apoptosis, in part by regulating the expression of Bcl‐2 and caspase‐3. Silencing of TUG 1 inhibited cell migration and invasion via the progression of epithelial–mesenchymal transition ( EMT ). Taken together, our findings indicate that TUG 1 acts as an oncogene in cervical cancer and may represent a novel therapeutic target." @default.
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- W2574252012 date "2017-01-15" @default.
- W2574252012 modified "2023-10-10" @default.
- W2574252012 title "Upregulation of long noncoding RNA TUG1 promotes cervical cancer cell proliferation and migration" @default.
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- W2574252012 doi "https://doi.org/10.1002/cam4.994" @default.
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