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- W2574278005 abstract "Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum yielding significant clinical benefits in patients with various malignancies by unleashing anti-tumor immunity. Galectins, a family of glycan-binding proteins, have emerged as novel regulatory checkpoints that promote immune evasive programs by inducing T-cell exhaustion, limiting T-cell survival, favoring expansion of regulatory T cells, de-activating natural killer cells and polarizing myeloid cells toward an immunosuppressive phenotype. Concomitantly, galectins can trigger vascular signaling programs, serving as bifunctional messengers that couple tumor immunity and angiogenesis. Thus, targeting galectin-glycan interactions may halt tumor progression by simultaneously augmenting antitumor immunity and suppressing aberrant angiogenesis." @default.
- W2574278005 created "2017-01-26" @default.
- W2574278005 creator A5024226262 @default.
- W2574278005 creator A5027398481 @default.
- W2574278005 creator A5068707033 @default.
- W2574278005 date "2017-04-01" @default.
- W2574278005 modified "2023-10-07" @default.
- W2574278005 title "Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis" @default.
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- W2574278005 doi "https://doi.org/10.1016/j.coi.2016.12.003" @default.
- W2574278005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28088061" @default.
- W2574278005 hasPublicationYear "2017" @default.
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