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- W2574304840 abstract "Platelets play important roles in hemostasis. After vessel wall damage, platelets rapidly adhere, aggregate, and secrete compounds that activate other platelets. This results in the formation of a platelet plug (primary hemostasis). In addition, activated platelets support the formation of insoluble fibrin (coagulation, secondary hemostasis) that strengthens the platelet plug. In the 1940s it was known that platelets support clotting, because platelet-containing plasma clotted faster than platelet-poor plasma (PPP). High-speed centrifugation of PPP further prolonged the clotting time, suggesting that PPP contained another (subcellular) factor that facilitated clotting.1,2 In 1967, Wolf3 demonstrated the presence of “coagulant material in minute particulate form,” which was present in “normal plasma, serum and fractions derived therefrom.” This material originated from platelets and was initially called platelet dust.3 The ability of platelets and platelet dust to facilitate coagulation was known in the early literature as platelet factor 3 activity. We now know that platelet dust consists of small vesicles that are mainly platelet derived (platelet-derived microparticles, or PMPs) and explain the coagulant activity of PPP. Especially during the last decade, there has been renewed interest in the potential role of PMP in health and disease." @default.
- W2574304840 created "2017-01-26" @default.
- W2574304840 creator A5003239706 @default.
- W2574304840 creator A5081799498 @default.
- W2574304840 date "2007-01-01" @default.
- W2574304840 modified "2023-09-26" @default.
- W2574304840 title "Platelet-Derived Microparticles" @default.
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- W2574304840 doi "https://doi.org/10.1016/b978-012369367-9/50782-5" @default.
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