FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2574403377> ?p ?o ?g. }

• W2574403377 endingPage "2350" @default.
• W2574403377 startingPage "2334" @default.
• W2574403377 abstract "The common practice of increasing dietary energy density during the close-up dry period (last ∼3 wk prepartum) has been recently associated with a higher incidence of metabolic disorders after calving. Despite these reports, over-feeding of metabolizable energy (ME) during the far-off, nonlactating period is a common management policy aimed at achieving optimum calving body condition score (BCS) in pasture-based systems, as cows are generally thinner than total mixed ration cows at the end of lactation. Our hypothesis was that both far-off and close-up overfeeding influence the peripartum adipose tissue changes associated with energy balance and inflammatory state. Sixty mid-lactation, grazing dairy cows of mixed age and breed were randomly allocated to 1 of 2 groups that were managed through late lactation to achieve a low and high BCS (approximately 4.25 and 5.0 on a 10-point scale) at dry-off. The low BCS cows were then overfed ME to ensure that they achieved the same BCS as the higher BCS group by calving. Within each rate of BCS gain treatment, cows were offered 65, 90, or 120% of their pre-calving ME requirements for 3 wk pre-calving in a 2 × 3 factorial arrangement of treatments (i.e., 10 cows/treatment). Subcutaneous adipose tissue was collected via biopsy at -1, 1, and 4 wk relative to parturition. Quantitative PCR was used to measure mRNA and microRNA expression of targets related to adipogenesis and inflammation. Cows overfed in the far-off period had increased expression of miR-143 and miR-378 prepartum (-1 wk) indicating greater adipogenesis, consistent with their rapid gain in BCS following dry-off. Furthermore, the lower postpartum expression of IL6, TNF, TLR4, TLR9, and miR-145, and a higher abundance of miR-99a indicated lower body fat mobilization in early lactation in the same group. In the close-up period, feeding either 65 or 120% of ME requirements caused changes in FASN, IL1B, IL6R, TLR9, and the microRNA miR-143, miR-155, and miR-378. Their respective expression patterns indicate a tentative negative-feedback mechanism in metabolically compromised, feed-restricted cows, and a possible immune-related stimulation of lipolysis in apparently static adipocytes in overfed cows. Data from cows fed 90% of ME requirements indicate the existence of a balance between lipolytic (inflammatory-related) and anti-lipolytic signals, to prime the mobilization machinery in light of imminent lactation. Overall, results indicate that far-off dry cow nutrition influences peripartum adipose tissue metabolism, with neither strategy negatively affecting the physiological adaptation to lactation. Furthermore, to ensure a favorable transition, cows should be subjected to a small feed restriction in the close-up period, irrespective of far-off nutritional management." @default.
• W2574403377 created "2017-01-26" @default.
• W2574403377 creator A5008351397 @default.
• W2574403377 creator A5019129035 @default.
• W2574403377 creator A5029859318 @default.
• W2574403377 creator A5039143575 @default.
• W2574403377 creator A5060812724 @default.
• W2574403377 creator A5064325910 @default.
• W2574403377 creator A5065945245 @default.
• W2574403377 creator A5076181042 @default.
• W2574403377 creator A5078504589 @default.
• W2574403377 creator A5080806829 @default.
• W2574403377 creator A5083096746 @default.
• W2574403377 date "2017-03-01" @default.
• W2574403377 modified "2023-10-12" @default.
• W2574403377 title "Far-off and close-up dry matter intake modulate indicators of immunometabolic adaptations to lactation in subcutaneous adipose tissue of pasture-based transition dairy cows" @default.
• W2574403377 cites W1521152347 @default.
• W2574403377 cites W1545606694 @default.
• W2574403377 cites W1569693056 @default.
• W2574403377 cites W1640689074 @default.
• W2574403377 cites W1965699498 @default.
• W2574403377 cites W1967404506 @default.
• W2574403377 cites W1974092523 @default.
• W2574403377 cites W1974395864 @default.
• W2574403377 cites W1975537939 @default.
• W2574403377 cites W1975730135 @default.
• W2574403377 cites W1978040036 @default.
• W2574403377 cites W1988774935 @default.
• W2574403377 cites W1990364364 @default.
• W2574403377 cites W2000252039 @default.
• W2574403377 cites W2003946092 @default.
• W2574403377 cites W2006142154 @default.
• W2574403377 cites W2017026391 @default.
• W2574403377 cites W2024055184 @default.
• W2574403377 cites W2025500736 @default.
• W2574403377 cites W2026640827 @default.
• W2574403377 cites W2034192004 @default.
• W2574403377 cites W2036160324 @default.
• W2574403377 cites W2038228231 @default.
• W2574403377 cites W2041647432 @default.
• W2574403377 cites W2045247536 @default.
• W2574403377 cites W2047254315 @default.
• W2574403377 cites W2047492268 @default.
• W2574403377 cites W2051051060 @default.
• W2574403377 cites W2053229516 @default.
• W2574403377 cites W2054289136 @default.
• W2574403377 cites W2056051702 @default.
• W2574403377 cites W2057217096 @default.
• W2574403377 cites W2057226698 @default.
• W2574403377 cites W2057819889 @default.
• W2574403377 cites W2067521961 @default.
• W2574403377 cites W2072440955 @default.
• W2574403377 cites W2075317528 @default.
• W2574403377 cites W2075842007 @default.
• W2574403377 cites W2075881404 @default.
• W2574403377 cites W2080137338 @default.
• W2574403377 cites W2086125606 @default.
• W2574403377 cites W2087661868 @default.
• W2574403377 cites W2092084431 @default.
• W2574403377 cites W2093230315 @default.
• W2574403377 cites W2098285533 @default.
• W2574403377 cites W2099856513 @default.
• W2574403377 cites W2101328621 @default.
• W2574403377 cites W2105811126 @default.
• W2574403377 cites W2108102649 @default.
• W2574403377 cites W2109756525 @default.
• W2574403377 cites W2109857525 @default.
• W2574403377 cites W2109911892 @default.
• W2574403377 cites W2120274515 @default.
• W2574403377 cites W2124808472 @default.
• W2574403377 cites W2128359660 @default.
• W2574403377 cites W2131275094 @default.
• W2574403377 cites W2136106484 @default.
• W2574403377 cites W2137188155 @default.
• W2574403377 cites W2146145007 @default.
• W2574403377 cites W2146278947 @default.
• W2574403377 cites W2152988512 @default.
• W2574403377 cites W2156280702 @default.
• W2574403377 cites W2158687493 @default.
• W2574403377 cites W2166094946 @default.
• W2574403377 cites W2170069771 @default.
• W2574403377 cites W2170550295 @default.
• W2574403377 cites W2181061302 @default.
• W2574403377 cites W2212628775 @default.
• W2574403377 cites W2309306045 @default.
• W2574403377 cites W2317381522 @default.
• W2574403377 doi "https://doi.org/10.3168/jds.2016-11790" @default.
• W2574403377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28088407" @default.
• W2574403377 hasPublicationYear "2017" @default.
• W2574403377 type Work @default.
• W2574403377 sameAs 2574403377 @default.
• W2574403377 citedByCount "26" @default.
• W2574403377 countsByYear W25744033772017 @default.
• W2574403377 countsByYear W25744033772018 @default.
• W2574403377 countsByYear W25744033772019 @default.
• W2574403377 countsByYear W25744033772020 @default.
• W2574403377 countsByYear W25744033772021 @default.
• W2574403377 countsByYear W25744033772022 @default.

• next