FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2574658045> ?p ?o ?g. }

• W2574658045 endingPage "112" @default.
• W2574658045 startingPage "103" @default.
• W2574658045 abstract "In this study, we compared the virulence in weaner pigs of the Pinar del Rio isolate and the virulent Margarita strain. The latter caused the Cuban classical swine fever (CSF) outbreak of 1993. Our results showed that the Pinar del Rio virus isolated during an endemic phase is clearly of low virulence. We analysed the complete nucleotide sequence of the Pinar del Rio virus isolated after persistence in newborn piglets, as well as the genome sequence of the inoculum. The consensus genome sequence of the Pinar del Rio virus remained completely unchanged after 28days of persistent infection in swine. More importantly, a unique poly-uridine tract was discovered in the 3'UTR of the Pinar del Rio virus, which was not found in the Margarita virus or any other known CSFV sequences. Based on RNA secondary structure prediction, the poly-uridine tract results in a long single-stranded intervening sequence (SS) between the stem-loops I and II of the 3'UTR, without major changes in the stem- loop structures when compared to the Margarita virus. The possible implications of this novel insertion on persistence and attenuation remain to be investigated. In addition, comparison of the amino acid sequence of the viral proteins Erns, E1, E2 and p7 of the Margarita and Pinar del Rio viruses showed that all non-conservative amino acid substitutions acquired by the Pinar del Rio isolate clustered in E2, with two of them being located within the B/C domain. Immunisation and cross-neutralisation experiments in pigs and rabbits suggest differences between these two viruses, which may be attributable to the amino acid differences observed in E2. Altogether, these data provide fresh insights into viral molecular features which might be associated with the attenuation and adaptation of CSFV for persistence in the field." @default.
• W2574658045 created "2017-01-26" @default.
• W2574658045 creator A5005781368 @default.
• W2574658045 creator A5012468987 @default.
• W2574658045 creator A5014435916 @default.
• W2574658045 creator A5014730744 @default.
• W2574658045 creator A5020620315 @default.
• W2574658045 creator A5023344241 @default.
• W2574658045 creator A5023889912 @default.
• W2574658045 creator A5027774052 @default.
• W2574658045 creator A5044594852 @default.
• W2574658045 creator A5048523334 @default.
• W2574658045 creator A5074927575 @default.
• W2574658045 creator A5079274040 @default.
• W2574658045 creator A5087350566 @default.
• W2574658045 creator A5087826669 @default.
• W2574658045 creator A5088265858 @default.
• W2574658045 creator A5089296981 @default.
• W2574658045 date "2017-03-01" @default.
• W2574658045 modified "2023-10-01" @default.
• W2574658045 title "Novel poly-uridine insertion in the 3′UTR and E2 amino acid substitutions in a low virulent classical swine fever virus" @default.
• W2574658045 cites W1004555258 @default.
• W2574658045 cites W1481291409 @default.
• W2574658045 cites W1608407313 @default.
• W2574658045 cites W1969202289 @default.
• W2574658045 cites W1976603877 @default.
• W2574658045 cites W1977209601 @default.
• W2574658045 cites W1977930354 @default.
• W2574658045 cites W1979266917 @default.
• W2574658045 cites W1986458846 @default.
• W2574658045 cites W1988444510 @default.
• W2574658045 cites W1989069389 @default.
• W2574658045 cites W1989609219 @default.
• W2574658045 cites W1990276309 @default.
• W2574658045 cites W2002596677 @default.
• W2574658045 cites W2008495981 @default.
• W2574658045 cites W2010133928 @default.
• W2574658045 cites W2015537591 @default.
• W2574658045 cites W2016616640 @default.
• W2574658045 cites W2025095074 @default.
• W2574658045 cites W2027055155 @default.
• W2574658045 cites W2030597005 @default.
• W2574658045 cites W2034792215 @default.
• W2574658045 cites W2039277389 @default.
• W2574658045 cites W2042984910 @default.
• W2574658045 cites W2046759764 @default.
• W2574658045 cites W2060597918 @default.
• W2574658045 cites W2063207147 @default.
• W2574658045 cites W2064233234 @default.
• W2574658045 cites W2066209323 @default.
• W2574658045 cites W2070943522 @default.
• W2574658045 cites W2073233589 @default.
• W2574658045 cites W2083465091 @default.
• W2574658045 cites W2086837310 @default.
• W2574658045 cites W2091779623 @default.
• W2574658045 cites W2094537279 @default.
• W2574658045 cites W2095936155 @default.
• W2574658045 cites W2103048257 @default.
• W2574658045 cites W2107931135 @default.
• W2574658045 cites W2121945933 @default.
• W2574658045 cites W2135553623 @default.
• W2574658045 cites W2141176661 @default.
• W2574658045 cites W2147742166 @default.
• W2574658045 cites W2159527899 @default.
• W2574658045 cites W2161317698 @default.
• W2574658045 cites W2162693599 @default.
• W2574658045 cites W2165495076 @default.
• W2574658045 cites W2165902807 @default.
• W2574658045 cites W2167214103 @default.
• W2574658045 cites W2167948304 @default.
• W2574658045 cites W2252301909 @default.
• W2574658045 cites W2255974537 @default.
• W2574658045 cites W2256756668 @default.
• W2574658045 cites W2278482689 @default.
• W2574658045 cites W2293422394 @default.
• W2574658045 cites W2295020188 @default.
• W2574658045 cites W2324845231 @default.
• W2574658045 doi "https://doi.org/10.1016/j.vetmic.2017.01.013" @default.
• W2574658045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28284595" @default.
• W2574658045 hasPublicationYear "2017" @default.
• W2574658045 type Work @default.
• W2574658045 sameAs 2574658045 @default.
• W2574658045 citedByCount "26" @default.
• W2574658045 countsByYear W25746580452017 @default.
• W2574658045 countsByYear W25746580452018 @default.
• W2574658045 countsByYear W25746580452019 @default.
• W2574658045 countsByYear W25746580452020 @default.
• W2574658045 countsByYear W25746580452021 @default.
• W2574658045 countsByYear W25746580452022 @default.
• W2574658045 crossrefType "journal-article" @default.
• W2574658045 hasAuthorship W2574658045A5005781368 @default.
• W2574658045 hasAuthorship W2574658045A5012468987 @default.
• W2574658045 hasAuthorship W2574658045A5014435916 @default.
• W2574658045 hasAuthorship W2574658045A5014730744 @default.
• W2574658045 hasAuthorship W2574658045A5020620315 @default.
• W2574658045 hasAuthorship W2574658045A5023344241 @default.
• W2574658045 hasAuthorship W2574658045A5023889912 @default.
• W2574658045 hasAuthorship W2574658045A5027774052 @default.

• next