FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2574877967> ?p ?o ?g. }

• W2574877967 endingPage "e1005" @default.
• W2574877967 startingPage "e1005" @default.
• W2574877967 abstract "Abstract Caregiver maltreatment induces vulnerability to later-life psychopathology. Clinical and preclinical evidence suggest changes in prefrontal and limbic circuitry underlie this susceptibility. We examined this question using a rat model of maternal maltreatment and methods translated from humans, resting-state functional magnetic resonance imaging (R-fMRI). Rat pups were reared by mothers provided with insufficient or abundant bedding for nest building from postnatal (PN) days 8 to 12 and underwent behavioral assessments of affect-related behaviors (forced swim, sucrose preference and social interaction) in adolescence (PN45) and early adulthood (PN60). R-fMRI sessions were conducted under light anesthesia at both ages. Offspring reared with insufficient bedding (that is, maltreated) displayed enduring negative affective behaviors. Amygdala-prefrontal cortex (PFC) functional connectivity increased significantly from adolescence to adulthood in controls, but not in maltreated animals. We computed the fractional amplitude of low-frequency fluctuations (fALFF), an index of intrinsic brain activity, and found that fALFF in medial prefrontal cortex and anterior cingulate cortex (MPFC/ACC) increased significantly with age in controls but remained unchanged in maltreated animals during adolescence and adulthood. We used a seed-based analysis to explore changes in functional connectivity between this region and the whole brain. Compared with controls, maltreated animals demonstrated reduced functional connectivity between MPFC/ACC and left caudate/putamen across both ages. Functional connectivity between MPFC/ACC and right caudate/putamen showed a group by age interaction: decreased in controls but increased in maltreated animals. These data suggest that maltreatment induces vulnerability to psychopathology and is associated with differential developmental trajectories of prefrontal and subcortical circuits underlying affect regulation." @default.
• W2574877967 created "2017-01-26" @default.
• W2574877967 creator A5006629992 @default.
• W2574877967 creator A5007082427 @default.
• W2574877967 creator A5024043736 @default.
• W2574877967 creator A5026706614 @default.
• W2574877967 creator A5043246060 @default.
• W2574877967 creator A5053340384 @default.
• W2574877967 creator A5056250258 @default.
• W2574877967 creator A5056989598 @default.
• W2574877967 creator A5060525920 @default.
• W2574877967 creator A5066423809 @default.
• W2574877967 creator A5076008547 @default.
• W2574877967 creator A5086675924 @default.
• W2574877967 date "2017-01-17" @default.
• W2574877967 modified "2023-10-17" @default.
• W2574877967 title "Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring" @default.
• W2574877967 cites W1022223611 @default.
• W2574877967 cites W1506262237 @default.
• W2574877967 cites W1708089852 @default.
• W2574877967 cites W1808637165 @default.
• W2574877967 cites W1854033343 @default.
• W2574877967 cites W1891681766 @default.
• W2574877967 cites W1892826918 @default.
• W2574877967 cites W1918921034 @default.
• W2574877967 cites W1966526686 @default.
• W2574877967 cites W1969032152 @default.
• W2574877967 cites W1971003071 @default.
• W2574877967 cites W1971552469 @default.
• W2574877967 cites W1976407450 @default.
• W2574877967 cites W1981459575 @default.
• W2574877967 cites W1987550068 @default.
• W2574877967 cites W1991472932 @default.
• W2574877967 cites W1991479884 @default.
• W2574877967 cites W1993984415 @default.
• W2574877967 cites W1997194251 @default.
• W2574877967 cites W1998980503 @default.
• W2574877967 cites W2008443876 @default.
• W2574877967 cites W2008912093 @default.
• W2574877967 cites W2009494091 @default.
• W2574877967 cites W2010067098 @default.
• W2574877967 cites W2015455914 @default.
• W2574877967 cites W2017690535 @default.
• W2574877967 cites W2017934537 @default.
• W2574877967 cites W2024365408 @default.
• W2574877967 cites W2028018776 @default.
• W2574877967 cites W2031067009 @default.
• W2574877967 cites W2034504866 @default.
• W2574877967 cites W2040527392 @default.
• W2574877967 cites W2044820817 @default.
• W2574877967 cites W2050959523 @default.
• W2574877967 cites W2052644075 @default.
• W2574877967 cites W2057550180 @default.
• W2574877967 cites W2057632757 @default.
• W2574877967 cites W2061679838 @default.
• W2574877967 cites W2063400326 @default.
• W2574877967 cites W2071300176 @default.
• W2574877967 cites W2072061544 @default.
• W2574877967 cites W2078612107 @default.
• W2574877967 cites W2081718320 @default.
• W2574877967 cites W2082117755 @default.
• W2574877967 cites W2089299823 @default.
• W2574877967 cites W2099201877 @default.
• W2574877967 cites W2100340252 @default.
• W2574877967 cites W2100634972 @default.
• W2574877967 cites W2101540672 @default.
• W2574877967 cites W2114221514 @default.
• W2574877967 cites W2117693696 @default.
• W2574877967 cites W2119279206 @default.
• W2574877967 cites W2129028793 @default.
• W2574877967 cites W2130299724 @default.
• W2574877967 cites W2131850183 @default.
• W2574877967 cites W2133371501 @default.
• W2574877967 cites W2137189967 @default.
• W2574877967 cites W2143527336 @default.
• W2574877967 cites W2143702906 @default.
• W2574877967 cites W2148389863 @default.
• W2574877967 cites W2149968182 @default.
• W2574877967 cites W2150379889 @default.
• W2574877967 cites W2150693380 @default.
• W2574877967 cites W2156241013 @default.
• W2574877967 cites W2158225336 @default.
• W2574877967 cites W2158678922 @default.
• W2574877967 cites W2159772210 @default.
• W2574877967 cites W2160546880 @default.
• W2574877967 cites W2166372248 @default.
• W2574877967 cites W2169787465 @default.
• W2574877967 cites W2171217262 @default.
• W2574877967 cites W2176484432 @default.
• W2574877967 cites W2176954879 @default.
• W2574877967 cites W2218776046 @default.
• W2574877967 cites W2290190425 @default.
• W2574877967 cites W2337323496 @default.
• W2574877967 cites W2420450499 @default.
• W2574877967 cites W2536901180 @default.
• W2574877967 cites W408724154 @default.
• W2574877967 cites W4235770099 @default.
• W2574877967 cites W4249709918 @default.

• next