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• W2575192017 abstract "SLEEP, Vol. 26, Abstract Supplement, 2003 A390 0983.R Near-Infrared Spectroscopy for the A~ssment of Vascular Respon- siveness of the Brain: A Screening Method for Cerebrovascular Morbidity in Obstructive Sleep Apnea Micha/os A,t.z Safonova LP,1 0 /opade CS,-1 Choi JH,t Ma11111lin WW, 1 Hueber DM, 1 Barbieri B,J Grauon £1 (I) Laboratory for Fluorescence Dynamics, Departmenr of Physics, Uni- versity of Illinois at Urbana-Champaign, (2) ISS, Inc. Champaign, Illi- nois, (3) Center for Sleep and Ventilatory Disorders, University of Illi- nois ·at Chicago Medical Center, College of Medicine Introduction: Obstructive Sleep Apnea Syndrome (OS/S) is an impor- tant risk factor for the development of cardiovascular morbidity and mortality. Compromised cerebral blood now (CBF) has been postulated to ac.c.ount for the cerebrovascular morbidity associated with OS/S. Near-infrared Spectroscopy (NIRS), a non-invasive, portable, cost· effective methodology that allows transcranial and continuous real-time measurements of brain tissue oxygenation and hemodynamics is the only modality that provides information on brain oxygenation. Hence, NIRS is an important tool for the assessment of c:erebrovascular health. Methods: A. Subjects: Twenty subjects (25-74yrs) participated in the study. Eight (29-74yrs) had OSAS (AHl>20), while twelve healthy non- snorers (25-54yrs) constituted the control group.B. Instrumentation and Monitoring: Arterial blood oxygen saturation (Sa02) and heart rate (HR) were monitored via pulse oximetry (N-200, Nellcor Inc., Pleasanton, CA), and the breathing rate with a respiratory strain gauge (Resp-EZ, Sleepmate, New-Life Technologies, Midlothian, VA). The NIRS param- eters, such as oxy-(f02Hb]), deoxy-([HHb]), total hemoglobin ((tllbJ) concentrations, and tissue hemoglobin oxygen saturation (S02) were monitored by a frequency-domain tissue oximeter (OxiplexTS, ISS Inc., Champaign, IL).C. Experimental protocol: All subjects were instructed to perform breath-holding exercises while vascular reactivity and cere- bral hemodyoamic responses to hypoxia and consequent hypercapnia (carbon dioxide is a vasodilator in the brain) was determined. The pro- tocol consisted of: 5-7 minutes normal breathing; 10-30! seconds of breath holding (at FRC); Resumption of normal breathing and repetition or breath holding (3-5 times). Results: Appropriate analysis schemes have been applied to differenti- ate cerebrovascular reactivity between the two groups and characterize the subjects. In healthy subjects, the brain responds to hypoxia and hypercapnia by vasodilalion and opening of the capillary bed. Normals in our study showed a prompt decrease in (HHb] and an increase in (02Hb] and (tHb]. These changes correlated with an increase in CBF to meet the oxygen demands of the brain. The decrease in [HHb] represents the wash-out effect from the increased CBF. Jn subjects with OSAS, the hemodynamic response to hypoxia was significantly delayed, reduced or even absent (p<0.040). Conclusions: Using simple breath holding exercises and a novel methodology, we showed that ccrebrovascular reactivity 10 hypoxia and hypercapnia is compromised in OSAS sufferers. O_u_r results suggest that compromised brain microvasculature in OSAS may lead to structural and functional impairment and diminished or loss of ability to vasodi- late. This finding may explain the increased cerebrovascular morbidity seen in OS/S. NIRS provides non-invasive, transcranial, real-time mea- surements of cerebral oxygenation and hemodynamics. It gives direct information on cerebrovascular health by monitoring the response of the brain to hypoxic insults. NIRS can provide a cost-effective screening method for individuals at risk for the cerebrovascular consequences of OSAS. A391 Research supported by NW grant NS40597 SLEEP, Vol. 26, Abstract Supplement, 2003" @default.
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• W2575192017 title "Near-infrared spectroscopy for the assessment of vascular responsiveness of the brain: A screening method for cerebrovascular morbidity in obstructive sleep Apnea" @default.
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