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- W2575236525 endingPage "630" @default.
- W2575236525 startingPage "622" @default.
- W2575236525 abstract "The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver parenchyma known as metabolic zonation which is often lost in liver diseases. Although this phenomenon is known for about 40 years, the underlying regulatory pathways are not yet fully elucidated. The physiologically occurring oxygen gradient was considered to be crucial for the appearance of zonation; however, a number of reports during the last decade indicating that β-catenin signaling, and the hedgehog (Hh) pathway contribute to metabolic zonation may have shifted this view. In the current review we connect these new observations with the concept that the oxygen gradient within the liver acinus is a regulator of zonation. This is underlined by a number of facts showing that the β-catenin and the Hh pathway can be modulated by the hypoxia signaling system and the hypoxia-inducible transcription factors (HIFs). Altogether, we provide a view by which the dynamic interplay between all these pathways can drive liver zonation and thus contribute to its physiological function." @default.
- W2575236525 created "2017-01-26" @default.
- W2575236525 creator A5046928222 @default.
- W2575236525 date "2017-04-01" @default.
- W2575236525 modified "2023-10-11" @default.
- W2575236525 title "Metabolic zonation of the liver: The oxygen gradient revisited" @default.
- W2575236525 cites W107868517 @default.
- W2575236525 cites W1211413901 @default.
- W2575236525 cites W145345561 @default.
- W2575236525 cites W1484691457 @default.
- W2575236525 cites W1502521862 @default.
- W2575236525 cites W1510072442 @default.
- W2575236525 cites W1536635467 @default.
- W2575236525 cites W1565212514 @default.
- W2575236525 cites W1901649215 @default.
- W2575236525 cites W1921817009 @default.
- W2575236525 cites W1932377803 @default.
- W2575236525 cites W1954286166 @default.
- W2575236525 cites W1963534821 @default.
- W2575236525 cites W1965827991 @default.
- W2575236525 cites W1968272852 @default.
- W2575236525 cites W1968461724 @default.
- W2575236525 cites W1969730342 @default.
- W2575236525 cites W1971958889 @default.
- W2575236525 cites W1972226898 @default.
- W2575236525 cites W1973021910 @default.
- W2575236525 cites W1973438950 @default.
- W2575236525 cites W1974549459 @default.
- W2575236525 cites W1975752208 @default.
- W2575236525 cites W1975853332 @default.
- W2575236525 cites W1975984062 @default.
- W2575236525 cites W1976226233 @default.
- W2575236525 cites W1981442583 @default.
- W2575236525 cites W1983075687 @default.
- W2575236525 cites W1983712244 @default.
- W2575236525 cites W1983748672 @default.
- W2575236525 cites W1984443589 @default.
- W2575236525 cites W1988237828 @default.
- W2575236525 cites W1988377666 @default.
- W2575236525 cites W1991066138 @default.
- W2575236525 cites W1991514473 @default.
- W2575236525 cites W1992888159 @default.
- W2575236525 cites W1994523098 @default.
- W2575236525 cites W1996285993 @default.
- W2575236525 cites W1996463890 @default.
- W2575236525 cites W1997208865 @default.
- W2575236525 cites W1997822977 @default.
- W2575236525 cites W1999335215 @default.
- W2575236525 cites W1999399027 @default.
- W2575236525 cites W2001690427 @default.
- W2575236525 cites W2001968579 @default.
- W2575236525 cites W2002008095 @default.
- W2575236525 cites W2003867270 @default.
- W2575236525 cites W2005729255 @default.
- W2575236525 cites W2008285918 @default.
- W2575236525 cites W2010356452 @default.
- W2575236525 cites W2013232839 @default.
- W2575236525 cites W2014516365 @default.
- W2575236525 cites W2015507138 @default.
- W2575236525 cites W2018504915 @default.
- W2575236525 cites W2018598424 @default.
- W2575236525 cites W2019784830 @default.
- W2575236525 cites W2020498032 @default.
- W2575236525 cites W2022137333 @default.
- W2575236525 cites W2023259982 @default.
- W2575236525 cites W2027121745 @default.
- W2575236525 cites W2031146967 @default.
- W2575236525 cites W2031402631 @default.
- W2575236525 cites W2031989994 @default.
- W2575236525 cites W2032648838 @default.
- W2575236525 cites W2033151981 @default.
- W2575236525 cites W2033453582 @default.
- W2575236525 cites W2033630167 @default.
- W2575236525 cites W2033958147 @default.
- W2575236525 cites W2033986601 @default.
- W2575236525 cites W2035305404 @default.
- W2575236525 cites W2035855731 @default.
- W2575236525 cites W2035991083 @default.
- W2575236525 cites W2039934786 @default.
- W2575236525 cites W2047962338 @default.
- W2575236525 cites W2048216460 @default.
- W2575236525 cites W2048375374 @default.
- W2575236525 cites W2048594557 @default.
- W2575236525 cites W2048684569 @default.
- W2575236525 cites W2050881696 @default.
- W2575236525 cites W2054987125 @default.
- W2575236525 cites W2058326304 @default.
- W2575236525 cites W2059155457 @default.
- W2575236525 cites W2061717797 @default.
- W2575236525 cites W2064272569 @default.
- W2575236525 cites W2064696266 @default.
- W2575236525 cites W2067162304 @default.
- W2575236525 cites W2067699988 @default.
- W2575236525 cites W2068127752 @default.
- W2575236525 cites W2069679898 @default.
- W2575236525 cites W2070919564 @default.
- W2575236525 cites W2072437542 @default.
- W2575236525 cites W2073910977 @default.