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- W2575347894 abstract "Some studies have documented that bethanechol chloride (BC) may be useful in preventing the incidence and/or severity of xerostomia (XT) with minimal side effects. However, BC action in irradiated patients with XT has not yet been determined (curative). In this study the efficacy of BC in irradiated patients, and salivary composition subsequent to drug administration were evaluated. In total, 45 irradiated patients complaining of XT used 50 mg/day of BC, for 3 months. XT and sialometry were evaluated in 4 phases. Biochemical analysis included buffering capacity, pH, total protein concentration (TP), amylase (AM), catalase (CT) and peroxidase (PX) activities. According to XT grading system used, patients showed improvement in XT in all experimental times (p<0.05) between Phase 1 and Phases 2 (p=0.031), 3 (p=0.015) and 4 (p=0.015). The TP concentration decreased; AM concentration increased (p <0.05); PX activity decreased (p <0.05), and CT increased after Phase 2, for stimulated saliva collection (p<0.05). Our results suggest that BC improved the XT of irradiated patients. The biochemical results are suggestive of improvement in parotid gland secretion. Financial support: FAPESP." @default.
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- W2575347894 date "2017-02-01" @default.
- W2575347894 modified "2023-09-25" @default.
- W2575347894 title "PP - INFLUENCE OF BETHANECHOL CHLORIDE IN SALIVARY COMPOSITION AND FLOW RATE IN IRRADIATED PATIENTS" @default.
- W2575347894 doi "https://doi.org/10.1016/j.oooo.2016.09.043" @default.
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