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- W2575360168 abstract "Delirium is a frequent outcome for aged and demented patients that suffer a systemic inflammatory insult. Animal models that reconstruct these etiological processes have potential to provide a better understanding of the pathophysiology of delirium. Therefore, we systematically reviewed animal studies in which systemic inflammation was superimposed on aged or diseased animal models. In total, 77 studies were identified. Aged animals were challenged with a bacterial endotoxin in 29 studies, 25 studies superimposed surgery on aged animals, and in 6 studies a bacterial infection, Escherichia coli (E. coli), was used. Diseased animals were challenged with a bacterial endotoxin in 15 studies, two studies examined effects of the cytokine IL-1β, and one study used polyinosinic:polycytidilic acid (poly I:C). This systematic review analyzed the impact of systemic inflammation on the production of inflammatory and neurotoxic mediators in peripheral blood, cerebrospinal fluid (CSF), and on the central nervous system (CNS). Moreover, concomitant behavioral and cognitive symptoms were also evaluated. Finally, outcomes of behavioral and cognitive tests from animal studies were compared to features and symptoms present in delirious patients." @default.
- W2575360168 created "2017-01-26" @default.
- W2575360168 creator A5012392552 @default.
- W2575360168 creator A5014763110 @default.
- W2575360168 creator A5024816178 @default.
- W2575360168 creator A5029380319 @default.
- W2575360168 creator A5055689793 @default.
- W2575360168 creator A5076556524 @default.
- W2575360168 date "2017-05-01" @default.
- W2575360168 modified "2023-10-05" @default.
- W2575360168 title "Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review" @default.
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