FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575370147> ?p ?o ?g. }

• W2575370147 abstract "Abstract Abstract 540 Background: Type 1 diabetes mellitus (T1DM) is a hypercoagulable state associated with increased acute cardiovascular events. Potential risk factors for this include alterations in coagulation and fibrinolytic systems. Tissue factor (TF) is the principal initiator of blood coagulation. Several studies show that there is a circulating pool of TF in blood, which is thrombogenic, and elevated in thrombotic states. We have shown (J Clin Endo Metab 2007, 92:4352-8) that circulating TF procoagulant activity (TF-PCA) is elevated in patients with Type 2 DM (T2DM) and increases further with acute combined hyperglycemia-hyperinsulinemia and selective hyperinsulinemia. There is currently no information on circulating TF-PCA levels and TF responses to hyperglycemia and/or hyperinsulinemia in patients with T1DM who are at comparable risk for cardiovascular events as T2DM patients. Objective: To investigate circulating TF-PCA and other coagulation factors under basal conditions and in response to acute selective hyperglycemia, selective hyperinsulinemia and combined hyperglycemia and hyperinsulinemia in T1DM. Methods: Three study protocols were used: 1) acute correction of hyperglycemia (with IV insulin) followed by 24 h of hyperglycemia, 2) 24 h of selective hyperinsulinemia and 3) 24 h of combined hyperinsulinemia and hyperglycemia. Studies were performed in 9 T1DM patients and 7 non-diabetic subjects. T1DM patients were on a basal/bolus insulin regimen (insulin glargine, 15–70 units at night) or Novolog 70/30 mix twice daily (45-50 units). Circulating membrane bound TF-PCA was measured in whole blood lysates by a two-stage clotting assay (Key et al, Blood; 1998:91). Results: Basal TF-PCA (64.7 ± 6.0 vs. 24.6 ± 1.2 U/ml, p < 0.001) and plasma factor VIIa (104 ± 24 vs. 38 ± 8 mU/ml, p < 0.03), the activated form of factor VII, were higher in T1DM (n=9) than in non-diabetic controls (n= 7) indicating a chronic procoagulant state. Plasma FVIIc, FVIII, thrombin-antithrombin complexes (TAT) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were not significantly different between patients and controls. When control subjects and T1DM patients were combined, HbA1C correlated with TF-PCA (r=0.71, p=0.0001, n=23). Plasma adiponectin was elevated in T1DM patients compared to control subjects (12.4 ± 1.9 vs 6.7 ± 2.0 μg/ml, p < 0.05). Acutely normalizing hyperglycemia in T1DM patients over 3–15 h did not decrease TF-PCA. There were also no changes in plasma FVIIc and FVIII. To explore effects of acutely raising plasma glucose, glucose was raised from 103 ± 8 to ∼ 300 mg/dl by infusion of 20% dextrose and maintained for 24 hours. Insulin concentrations were kept at basal concentrations (6 and 13 μU/ml) by IV infusion. In our previous studies in non-diabetic subjects (Diabetes 2006, 55,202-8) and in T2DM patients (J Clin Endo Metab 2007, 92,4352-8), raising glucose and insulin together produced a marked increase in circulating TF-PCA. We therefore raised glucose to ∼ 250 mg/dl and insulin to ∼ 100 μU/ml together in 8 T1DM patients. Raising glucose levels alone or in combination with insulin decreased circulating TF-PCA by 26% (p < 0.02) and 37% (p < 0.01), respectively, which is in striking contrast to the elevations noted in non-diabetic controls and T2DM patients. To explore effects of selective hyperinsulinemia, plasma insulin levels were raised in 3 T1DM patients by IV infusion of regular insulin from 15 ± 0.2 to ∼ 75 μU/ml and maintained for 24 hours while plasma glucose was kept at ∼ 100 mg by infusion of 20% dextrose. Again, in contrast to our studies in T2DM patients and healthy subjects we found no increase in TF-PCA Conclusions: Circulating TF-PCA and FVIIa levels are elevated in T1DM patients indicating a potential prothrombotic state. The studies on acutely induced hyperinsulinemia and hyperglycemia indicate that the regulation of TF expression is different in T1DM and T2DM. This may be due to multiple mechanisms, including a differential effect of insulin on monocytes TF expression in T1DM and T2DM, and due to differences in plasma adiponectin, which has been shown to inhibit TF expression and is elevated in T1DM. Additional studies are needed to obtain insights into the mechanisms regulating the differential expression of TF in the two forms of diabetes. Disclosures: No relevant conflicts of interest to declare." @default.
• W2575370147 created "2017-01-26" @default.
• W2575370147 creator A5050280430 @default.
• W2575370147 creator A5058417787 @default.
• W2575370147 creator A5072579760 @default.
• W2575370147 creator A5083612093 @default.
• W2575370147 creator A5090080754 @default.
• W2575370147 date "2011-11-18" @default.
• W2575370147 modified "2023-10-01" @default.
• W2575370147 title "Circulating Tissue Factor Procoagulant Activity (TF-PCA) Is Elevated in Type 1 Diabetes Mellitus: Differential Regulation of TF-PCA in Type 1 and Type 2 Diabetes" @default.
• W2575370147 doi "https://doi.org/10.1182/blood.v118.21.540.540" @default.
• W2575370147 hasPublicationYear "2011" @default.
• W2575370147 type Work @default.
• W2575370147 sameAs 2575370147 @default.
• W2575370147 citedByCount "0" @default.
• W2575370147 crossrefType "journal-article" @default.
• W2575370147 hasAuthorship W2575370147A5050280430 @default.
• W2575370147 hasAuthorship W2575370147A5058417787 @default.
• W2575370147 hasAuthorship W2575370147A5072579760 @default.
• W2575370147 hasAuthorship W2575370147A5083612093 @default.
• W2575370147 hasAuthorship W2575370147A5090080754 @default.
• W2575370147 hasConcept C126322002 @default.
• W2575370147 hasConcept C134018914 @default.
• W2575370147 hasConcept C186738567 @default.
• W2575370147 hasConcept C2777391703 @default.
• W2575370147 hasConcept C2778382381 @default.
• W2575370147 hasConcept C2779306644 @default.
• W2575370147 hasConcept C2780988686 @default.
• W2575370147 hasConcept C2781232474 @default.
• W2575370147 hasConcept C555293320 @default.
• W2575370147 hasConcept C71924100 @default.
• W2575370147 hasConceptScore W2575370147C126322002 @default.
• W2575370147 hasConceptScore W2575370147C134018914 @default.
• W2575370147 hasConceptScore W2575370147C186738567 @default.
• W2575370147 hasConceptScore W2575370147C2777391703 @default.
• W2575370147 hasConceptScore W2575370147C2778382381 @default.
• W2575370147 hasConceptScore W2575370147C2779306644 @default.
• W2575370147 hasConceptScore W2575370147C2780988686 @default.
• W2575370147 hasConceptScore W2575370147C2781232474 @default.
• W2575370147 hasConceptScore W2575370147C555293320 @default.
• W2575370147 hasConceptScore W2575370147C71924100 @default.
• W2575370147 hasLocation W25753701471 @default.
• W2575370147 hasOpenAccess W2575370147 @default.
• W2575370147 hasPrimaryLocation W25753701471 @default.
• W2575370147 hasRelatedWork W1983245574 @default.
• W2575370147 hasRelatedWork W2004752707 @default.
• W2575370147 hasRelatedWork W2051591968 @default.
• W2575370147 hasRelatedWork W2063528712 @default.
• W2575370147 hasRelatedWork W2069088504 @default.
• W2575370147 hasRelatedWork W2070097356 @default.
• W2575370147 hasRelatedWork W2109246857 @default.
• W2575370147 hasRelatedWork W2157421189 @default.
• W2575370147 hasRelatedWork W2157918275 @default.
• W2575370147 hasRelatedWork W2258460382 @default.
• W2575370147 hasRelatedWork W2329541529 @default.
• W2575370147 hasRelatedWork W2371476356 @default.
• W2575370147 hasRelatedWork W2373393002 @default.
• W2575370147 hasRelatedWork W2561157474 @default.
• W2575370147 hasRelatedWork W2583042218 @default.
• W2575370147 hasRelatedWork W2587535160 @default.
• W2575370147 hasRelatedWork W2793906803 @default.
• W2575370147 hasRelatedWork W2887571597 @default.
• W2575370147 hasRelatedWork W2979795610 @default.
• W2575370147 hasRelatedWork W3029162627 @default.
• W2575370147 isParatext "false" @default.
• W2575370147 isRetracted "false" @default.
• W2575370147 magId "2575370147" @default.
• W2575370147 workType "article" @default.