FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575403906> ?p ?o ?g. }

• W2575403906 endingPage "29" @default.
• W2575403906 startingPage "29" @default.
• W2575403906 abstract "The Escherichia coli RnlA-RnlB toxin–antitoxin system is related to the anti-phage mechanism. Under normal growth conditions, an RnlA toxin with endoribonuclease activity is inhibited by binding of its cognate RnlB antitoxin. After bacteriophage T4 infection, RnlA is activated by the disappearance of RnlB, resulting in the rapid degradation of T4 mRNAs and consequently no T4 propagation when T4 dmd encoding a phage antitoxin against RnlA is defective. Intriguingly, E. coli RNase HI, which plays a key role in DNA replication, is required for the activation of RnlA and stimulates the RNA cleavage activity of RnlA. Here, we report an additional role of RNase HI in the regulation of RnlA-RnlB system. Both RNase HI and RnlB are associated with NRD (one of three domains of RnlA). The interaction between RnlB and NRD depends on RNase HI. Exogenous expression of RnlA in wild-type cells has no effect on cell growth because of endogenous RnlB and this inhibition of RnlA toxicity requires RNase HI and NRD. These results suggest that RNase HI recruits RnlB to RnlA through NRD for inhibiting RnlA toxicity and thus plays two contrary roles in the regulation of RnlA-RnlB system." @default.
• W2575403906 created "2017-01-26" @default.
• W2575403906 creator A5020139068 @default.
• W2575403906 creator A5045669662 @default.
• W2575403906 creator A5054120210 @default.
• W2575403906 creator A5062356470 @default.
• W2575403906 date "2017-01-11" @default.
• W2575403906 modified "2023-09-27" @default.
• W2575403906 title "RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin–Antitoxin Module Requires RNase HI for Inhibition of RnlA Toxin Activity" @default.
• W2575403906 cites W1518445763 @default.
• W2575403906 cites W1527231409 @default.
• W2575403906 cites W1599154134 @default.
• W2575403906 cites W1604915411 @default.
• W2575403906 cites W1669746447 @default.
• W2575403906 cites W1725358412 @default.
• W2575403906 cites W1822103663 @default.
• W2575403906 cites W1858758914 @default.
• W2575403906 cites W1922621074 @default.
• W2575403906 cites W1944111347 @default.
• W2575403906 cites W1977293483 @default.
• W2575403906 cites W1977726874 @default.
• W2575403906 cites W1982148012 @default.
• W2575403906 cites W1982583457 @default.
• W2575403906 cites W1984831154 @default.
• W2575403906 cites W1991747510 @default.
• W2575403906 cites W1996890828 @default.
• W2575403906 cites W2015036927 @default.
• W2575403906 cites W2016691753 @default.
• W2575403906 cites W2017165733 @default.
• W2575403906 cites W2021670925 @default.
• W2575403906 cites W2027422709 @default.
• W2575403906 cites W2028198542 @default.
• W2575403906 cites W2061399892 @default.
• W2575403906 cites W2062119690 @default.
• W2575403906 cites W2064300165 @default.
• W2575403906 cites W2066845647 @default.
• W2575403906 cites W2069146829 @default.
• W2575403906 cites W2071684275 @default.
• W2575403906 cites W2111555302 @default.
• W2575403906 cites W2112724277 @default.
• W2575403906 cites W2132401377 @default.
• W2575403906 cites W2133896411 @default.
• W2575403906 cites W2135133274 @default.
• W2575403906 cites W2136833370 @default.
• W2575403906 cites W2146276053 @default.
• W2575403906 cites W2151981395 @default.
• W2575403906 cites W2155427359 @default.
• W2575403906 cites W2160084442 @default.
• W2575403906 cites W2164502256 @default.
• W2575403906 cites W2166606642 @default.
• W2575403906 cites W2171186968 @default.
• W2575403906 cites W2384121742 @default.
• W2575403906 doi "https://doi.org/10.3390/toxins9010029" @default.
• W2575403906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5308261" @default.
• W2575403906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28085056" @default.
• W2575403906 hasPublicationYear "2017" @default.
• W2575403906 type Work @default.
• W2575403906 sameAs 2575403906 @default.
• W2575403906 citedByCount "7" @default.
• W2575403906 countsByYear W25754039062017 @default.
• W2575403906 countsByYear W25754039062020 @default.
• W2575403906 countsByYear W25754039062021 @default.
• W2575403906 countsByYear W25754039062023 @default.
• W2575403906 crossrefType "journal-article" @default.
• W2575403906 hasAuthorship W2575403906A5020139068 @default.
• W2575403906 hasAuthorship W2575403906A5045669662 @default.
• W2575403906 hasAuthorship W2575403906A5054120210 @default.
• W2575403906 hasAuthorship W2575403906A5062356470 @default.
• W2575403906 hasBestOaLocation W25754039061 @default.
• W2575403906 hasConcept C104317684 @default.
• W2575403906 hasConcept C10879258 @default.
• W2575403906 hasConcept C153911025 @default.
• W2575403906 hasConcept C166703698 @default.
• W2575403906 hasConcept C195500695 @default.
• W2575403906 hasConcept C2777367657 @default.
• W2575403906 hasConcept C2778973234 @default.
• W2575403906 hasConcept C2780102198 @default.
• W2575403906 hasConcept C547475151 @default.
• W2575403906 hasConcept C55493867 @default.
• W2575403906 hasConcept C67705224 @default.
• W2575403906 hasConcept C69766542 @default.
• W2575403906 hasConcept C79750893 @default.
• W2575403906 hasConcept C86803240 @default.
• W2575403906 hasConcept C89423630 @default.
• W2575403906 hasConceptScore W2575403906C104317684 @default.
• W2575403906 hasConceptScore W2575403906C10879258 @default.
• W2575403906 hasConceptScore W2575403906C153911025 @default.
• W2575403906 hasConceptScore W2575403906C166703698 @default.
• W2575403906 hasConceptScore W2575403906C195500695 @default.
• W2575403906 hasConceptScore W2575403906C2777367657 @default.
• W2575403906 hasConceptScore W2575403906C2778973234 @default.
• W2575403906 hasConceptScore W2575403906C2780102198 @default.
• W2575403906 hasConceptScore W2575403906C547475151 @default.
• W2575403906 hasConceptScore W2575403906C55493867 @default.
• W2575403906 hasConceptScore W2575403906C67705224 @default.
• W2575403906 hasConceptScore W2575403906C69766542 @default.
• W2575403906 hasConceptScore W2575403906C79750893 @default.
• W2575403906 hasConceptScore W2575403906C86803240 @default.

• next