Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575425394> ?p ?o ?g. }
- W2575425394 endingPage "633" @default.
- W2575425394 startingPage "629" @default.
- W2575425394 abstract "Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study, we investigated the role of formyl peptide receptor (FPR)-mediated signaling in the maintenance of PP GCs, because FPRs recognize the microbiota and initiate an innate immune response by chemotaxis. We found that follicular dendritic cells (FDCs), a key organizer of B cell follicles and GCs in mucosal immunity, express Fpr2. Additionally, Fpr2-mediated signaling in PP FDCs promoted Cxcl13 and B cell activating factor expression, as well as B cell proliferation and activation. Therefore, we suggest that Fpr2-mediated signaling in FDCs plays a key role in GC maintenance in PPs and results in an Ag-specific IgA response in the gut mucosal immune compartment." @default.
- W2575425394 created "2017-01-26" @default.
- W2575425394 creator A5008964292 @default.
- W2575425394 creator A5015748204 @default.
- W2575425394 creator A5030863704 @default.
- W2575425394 date "2016-12-14" @default.
- W2575425394 modified "2023-10-16" @default.
- W2575425394 title "Cutting Edge: LL-37–Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer’s Patch Germinal Centers" @default.
- W2575425394 cites W1978740584 @default.
- W2575425394 cites W1979217507 @default.
- W2575425394 cites W1988215618 @default.
- W2575425394 cites W1996562688 @default.
- W2575425394 cites W2000906546 @default.
- W2575425394 cites W2001286841 @default.
- W2575425394 cites W2013424910 @default.
- W2575425394 cites W2021800929 @default.
- W2575425394 cites W2029320721 @default.
- W2575425394 cites W2032280932 @default.
- W2575425394 cites W2034662723 @default.
- W2575425394 cites W2039748606 @default.
- W2575425394 cites W2041852726 @default.
- W2575425394 cites W2045943349 @default.
- W2575425394 cites W2047889730 @default.
- W2575425394 cites W2050435980 @default.
- W2575425394 cites W2053044114 @default.
- W2575425394 cites W2088681135 @default.
- W2575425394 cites W2090324342 @default.
- W2575425394 cites W2106579717 @default.
- W2575425394 cites W2129509656 @default.
- W2575425394 cites W2138071207 @default.
- W2575425394 cites W2142181216 @default.
- W2575425394 cites W2143047964 @default.
- W2575425394 cites W2151231994 @default.
- W2575425394 cites W2158796516 @default.
- W2575425394 cites W2169759699 @default.
- W2575425394 cites W2212632191 @default.
- W2575425394 cites W61112106 @default.
- W2575425394 doi "https://doi.org/10.4049/jimmunol.1600886" @default.
- W2575425394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27974458" @default.
- W2575425394 hasPublicationYear "2016" @default.
- W2575425394 type Work @default.
- W2575425394 sameAs 2575425394 @default.
- W2575425394 citedByCount "26" @default.
- W2575425394 countsByYear W25754253942017 @default.
- W2575425394 countsByYear W25754253942018 @default.
- W2575425394 countsByYear W25754253942019 @default.
- W2575425394 countsByYear W25754253942020 @default.
- W2575425394 countsByYear W25754253942021 @default.
- W2575425394 countsByYear W25754253942022 @default.
- W2575425394 countsByYear W25754253942023 @default.
- W2575425394 crossrefType "journal-article" @default.
- W2575425394 hasAuthorship W2575425394A5008964292 @default.
- W2575425394 hasAuthorship W2575425394A5015748204 @default.
- W2575425394 hasAuthorship W2575425394A5030863704 @default.
- W2575425394 hasBestOaLocation W25754253941 @default.
- W2575425394 hasConcept C153911025 @default.
- W2575425394 hasConcept C159654299 @default.
- W2575425394 hasConcept C170493617 @default.
- W2575425394 hasConcept C185592680 @default.
- W2575425394 hasConcept C203014093 @default.
- W2575425394 hasConcept C2776090121 @default.
- W2575425394 hasConcept C2778019737 @default.
- W2575425394 hasConcept C2778453870 @default.
- W2575425394 hasConcept C3753494 @default.
- W2575425394 hasConcept C55493867 @default.
- W2575425394 hasConcept C67662055 @default.
- W2575425394 hasConcept C86803240 @default.
- W2575425394 hasConcept C8891405 @default.
- W2575425394 hasConcept C95444343 @default.
- W2575425394 hasConcept C96926380 @default.
- W2575425394 hasConceptScore W2575425394C153911025 @default.
- W2575425394 hasConceptScore W2575425394C159654299 @default.
- W2575425394 hasConceptScore W2575425394C170493617 @default.
- W2575425394 hasConceptScore W2575425394C185592680 @default.
- W2575425394 hasConceptScore W2575425394C203014093 @default.
- W2575425394 hasConceptScore W2575425394C2776090121 @default.
- W2575425394 hasConceptScore W2575425394C2778019737 @default.
- W2575425394 hasConceptScore W2575425394C2778453870 @default.
- W2575425394 hasConceptScore W2575425394C3753494 @default.
- W2575425394 hasConceptScore W2575425394C55493867 @default.
- W2575425394 hasConceptScore W2575425394C67662055 @default.
- W2575425394 hasConceptScore W2575425394C86803240 @default.
- W2575425394 hasConceptScore W2575425394C8891405 @default.
- W2575425394 hasConceptScore W2575425394C95444343 @default.
- W2575425394 hasConceptScore W2575425394C96926380 @default.
- W2575425394 hasIssue "2" @default.
- W2575425394 hasLocation W25754253941 @default.
- W2575425394 hasOpenAccess W2575425394 @default.
- W2575425394 hasPrimaryLocation W25754253941 @default.
- W2575425394 hasRelatedWork W123362614 @default.
- W2575425394 hasRelatedWork W1495768189 @default.
- W2575425394 hasRelatedWork W1504136545 @default.
- W2575425394 hasRelatedWork W1521392428 @default.
- W2575425394 hasRelatedWork W1576377498 @default.
- W2575425394 hasRelatedWork W1664114449 @default.
- W2575425394 hasRelatedWork W2171309116 @default.
- W2575425394 hasRelatedWork W2468424480 @default.
- W2575425394 hasRelatedWork W3129977619 @default.