Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575481614> ?p ?o ?g. }
- W2575481614 endingPage "19" @default.
- W2575481614 startingPage "9" @default.
- W2575481614 abstract "Extracellular adenosine 5'-triphosphate (ATP) and adenosine molecules are intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is released during hypoxic condition and by necrotic cells, as well as by activated immune cells and endothelial cells. However, under certain conditions, for instance at low concentrations or at prolonged exposure, ATP may also have anti-inflammatory properties. Extracellular ATP can activate both P2X and P2Y purinergic receptors. Extracellular ATP can be hydrolyzed into adenosine in a two-step enzymatic process involving the ectonucleotidases CD39 (ecto-apyrase) and CD73. These enzymes are expressed by many cell types, including endothelial cells and immune cells. The counterpart of ATP is adenosine, which is produced by breakdown of intra- or extracellular ATP. Adenosine has mainly anti-inflammatory effects by binding to the adenosine, or P1, receptors (A1, A2A, A2B, and A3). These receptors are also expressed in many cells, including immune cells. The final effect of ATP and adenosine in immune responses depends on the fine regulatory balance between the 2 molecules. In the present review, we will discuss the current knowledge on the role of these 2 molecules in the immune responses." @default.
- W2575481614 created "2017-01-26" @default.
- W2575481614 creator A5002327084 @default.
- W2575481614 creator A5050797896 @default.
- W2575481614 creator A5055933789 @default.
- W2575481614 date "2017-06-01" @default.
- W2575481614 modified "2023-10-02" @default.
- W2575481614 title "Extracellular ATP and adenosine: The Yin and Yang in immune responses?" @default.
- W2575481614 cites W1495057561 @default.
- W2575481614 cites W1514665208 @default.
- W2575481614 cites W1520157843 @default.
- W2575481614 cites W1550108534 @default.
- W2575481614 cites W1551550807 @default.
- W2575481614 cites W1557747032 @default.
- W2575481614 cites W1593579053 @default.
- W2575481614 cites W1602068304 @default.
- W2575481614 cites W1608870321 @default.
- W2575481614 cites W1781888289 @default.
- W2575481614 cites W182277502 @default.
- W2575481614 cites W1824528611 @default.
- W2575481614 cites W1877412971 @default.
- W2575481614 cites W1913353167 @default.
- W2575481614 cites W1933610294 @default.
- W2575481614 cites W1964663565 @default.
- W2575481614 cites W1965645997 @default.
- W2575481614 cites W1965834069 @default.
- W2575481614 cites W1968304355 @default.
- W2575481614 cites W1969485182 @default.
- W2575481614 cites W1969645166 @default.
- W2575481614 cites W1970009229 @default.
- W2575481614 cites W1970027494 @default.
- W2575481614 cites W1970488832 @default.
- W2575481614 cites W1971084572 @default.
- W2575481614 cites W1974608857 @default.
- W2575481614 cites W1975225567 @default.
- W2575481614 cites W1977686722 @default.
- W2575481614 cites W1977935209 @default.
- W2575481614 cites W1979412100 @default.
- W2575481614 cites W1982731795 @default.
- W2575481614 cites W1983602414 @default.
- W2575481614 cites W1984970610 @default.
- W2575481614 cites W1987062630 @default.
- W2575481614 cites W1987518018 @default.
- W2575481614 cites W1989149160 @default.
- W2575481614 cites W1990729707 @default.
- W2575481614 cites W1991017191 @default.
- W2575481614 cites W1995941325 @default.
- W2575481614 cites W1996085928 @default.
- W2575481614 cites W2001776200 @default.
- W2575481614 cites W2004900242 @default.
- W2575481614 cites W2005225272 @default.
- W2575481614 cites W2006224519 @default.
- W2575481614 cites W2007301952 @default.
- W2575481614 cites W2017177951 @default.
- W2575481614 cites W2017909062 @default.
- W2575481614 cites W2018607502 @default.
- W2575481614 cites W2022159206 @default.
- W2575481614 cites W2022431217 @default.
- W2575481614 cites W2022548397 @default.
- W2575481614 cites W2023214087 @default.
- W2575481614 cites W2023377074 @default.
- W2575481614 cites W2024461475 @default.
- W2575481614 cites W2026829929 @default.
- W2575481614 cites W2027518725 @default.
- W2575481614 cites W2028222722 @default.
- W2575481614 cites W2029695719 @default.
- W2575481614 cites W2029733235 @default.
- W2575481614 cites W2029913563 @default.
- W2575481614 cites W2030331927 @default.
- W2575481614 cites W2031434196 @default.
- W2575481614 cites W2031462278 @default.
- W2575481614 cites W2033336974 @default.
- W2575481614 cites W2034321048 @default.
- W2575481614 cites W2034442219 @default.
- W2575481614 cites W2034643457 @default.
- W2575481614 cites W2034741833 @default.
- W2575481614 cites W2036414840 @default.
- W2575481614 cites W2036700466 @default.
- W2575481614 cites W2038647312 @default.
- W2575481614 cites W2042906495 @default.
- W2575481614 cites W2043445250 @default.
- W2575481614 cites W2045576152 @default.
- W2575481614 cites W2048584025 @default.
- W2575481614 cites W2051529467 @default.
- W2575481614 cites W2054571187 @default.
- W2575481614 cites W2055692928 @default.
- W2575481614 cites W2059030264 @default.
- W2575481614 cites W2059612473 @default.
- W2575481614 cites W2061506872 @default.
- W2575481614 cites W2062761137 @default.
- W2575481614 cites W2063557216 @default.
- W2575481614 cites W2066502054 @default.
- W2575481614 cites W2066682307 @default.
- W2575481614 cites W2070663123 @default.
- W2575481614 cites W2070915732 @default.
- W2575481614 cites W2072862624 @default.
- W2575481614 cites W2073042805 @default.
- W2575481614 cites W2076256977 @default.