Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575488534> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2575488534 endingPage "62" @default.
- W2575488534 startingPage "56" @default.
- W2575488534 abstract "A cytokine screening on human peripheral blood mononuclear cells (PBMCs) stimulated with selected scorpion toxins (ScTx's) was performed in order to evaluate their effect on human immune cells. The ScTx's chosen for this report were three typical buthid scorpion venom peptides, one with lethal effects on mammals Centruroides suffussus suffusus toxin II (CssII), another, with lethal effects on insects and crustaceans Centruroides noxius toxin 5 (Cn5), and one more without lethal effects Tityus discrepans toxin (Discrepin). A Luminex multiplex analysis was performed in order to determine the amounts chemokines and cytokines IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12-p40, IL-13, interferon alpha (IFN-α), interferon gamma (IFN-γ), tumor necrosis factor alpha TNF-α, and interferon-inducible protein-10 (IP-10) secreted from human PBMCs exposed to these toxins. Although, the ScTx Cn5 is not lethal for mammals, it was able to induce the secretion of cytokines IL-1β, IL-6, and TNF-α, IL-10 and IP-10 in comparison to the lethal CssII, which was able to induce only IP-10 secretion. Discrepin also was able to induce only IP-10. Interestingly, only low amounts of interferons α and β were induced in the presence of the ScTx's assayed. In a synergic experiment, the combination of Discrepin and Cn5 displayed considerable reverse effects on induction of IL-1β, IL-6, IL-10 and TNF-α, but they had a slight synergic effect on IP-10 cytokine production in comparison with the single effect obtained with the Cn5 alone. Thus, the results obtained suggest that the profile of secreted cytokines promoted by ScTx Cn5 is highly related with a cytokine storm event, and also it suggests that the mammalian lethal neurotoxins are not solely responsible of the scorpion envenomation symptomatology." @default.
- W2575488534 created "2017-01-26" @default.
- W2575488534 creator A5031108776 @default.
- W2575488534 creator A5068386246 @default.
- W2575488534 date "2017-03-01" @default.
- W2575488534 modified "2023-10-03" @default.
- W2575488534 title "Selected scorpion toxin exposures induce cytokine release in human peripheral blood mononuclear cells" @default.
- W2575488534 cites W1762363712 @default.
- W2575488534 cites W1970360839 @default.
- W2575488534 cites W1974937986 @default.
- W2575488534 cites W1985030490 @default.
- W2575488534 cites W1997810187 @default.
- W2575488534 cites W1998292348 @default.
- W2575488534 cites W2007457726 @default.
- W2575488534 cites W2019770256 @default.
- W2575488534 cites W2042602533 @default.
- W2575488534 cites W2042894552 @default.
- W2575488534 cites W2043001568 @default.
- W2575488534 cites W2048211729 @default.
- W2575488534 cites W2055187724 @default.
- W2575488534 cites W2061080731 @default.
- W2575488534 cites W2061276929 @default.
- W2575488534 cites W2072790424 @default.
- W2575488534 cites W2074841582 @default.
- W2575488534 cites W2083828993 @default.
- W2575488534 cites W2084368010 @default.
- W2575488534 cites W2090657368 @default.
- W2575488534 cites W2091099975 @default.
- W2575488534 cites W2129239355 @default.
- W2575488534 cites W2139281297 @default.
- W2575488534 cites W2147453764 @default.
- W2575488534 cites W2160720438 @default.
- W2575488534 cites W2168420558 @default.
- W2575488534 cites W2169996531 @default.
- W2575488534 cites W2279591454 @default.
- W2575488534 doi "https://doi.org/10.1016/j.toxicon.2017.01.007" @default.
- W2575488534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28088477" @default.
- W2575488534 hasPublicationYear "2017" @default.
- W2575488534 type Work @default.
- W2575488534 sameAs 2575488534 @default.
- W2575488534 citedByCount "9" @default.
- W2575488534 countsByYear W25754885342017 @default.
- W2575488534 countsByYear W25754885342018 @default.
- W2575488534 countsByYear W25754885342020 @default.
- W2575488534 countsByYear W25754885342022 @default.
- W2575488534 crossrefType "journal-article" @default.
- W2575488534 hasAuthorship W2575488534A5031108776 @default.
- W2575488534 hasAuthorship W2575488534A5068386246 @default.
- W2575488534 hasConcept C137061746 @default.
- W2575488534 hasConcept C17991360 @default.
- W2575488534 hasConcept C202751555 @default.
- W2575488534 hasConcept C203014093 @default.
- W2575488534 hasConcept C2776178377 @default.
- W2575488534 hasConcept C2777367657 @default.
- W2575488534 hasConcept C2778690821 @default.
- W2575488534 hasConcept C2779448229 @default.
- W2575488534 hasConcept C49039625 @default.
- W2575488534 hasConcept C55493867 @default.
- W2575488534 hasConcept C86803240 @default.
- W2575488534 hasConcept C8891405 @default.
- W2575488534 hasConcept C89423630 @default.
- W2575488534 hasConcept C98274493 @default.
- W2575488534 hasConceptScore W2575488534C137061746 @default.
- W2575488534 hasConceptScore W2575488534C17991360 @default.
- W2575488534 hasConceptScore W2575488534C202751555 @default.
- W2575488534 hasConceptScore W2575488534C203014093 @default.
- W2575488534 hasConceptScore W2575488534C2776178377 @default.
- W2575488534 hasConceptScore W2575488534C2777367657 @default.
- W2575488534 hasConceptScore W2575488534C2778690821 @default.
- W2575488534 hasConceptScore W2575488534C2779448229 @default.
- W2575488534 hasConceptScore W2575488534C49039625 @default.
- W2575488534 hasConceptScore W2575488534C55493867 @default.
- W2575488534 hasConceptScore W2575488534C86803240 @default.
- W2575488534 hasConceptScore W2575488534C8891405 @default.
- W2575488534 hasConceptScore W2575488534C89423630 @default.
- W2575488534 hasConceptScore W2575488534C98274493 @default.
- W2575488534 hasLocation W25754885341 @default.
- W2575488534 hasLocation W25754885342 @default.
- W2575488534 hasOpenAccess W2575488534 @default.
- W2575488534 hasPrimaryLocation W25754885341 @default.
- W2575488534 hasRelatedWork W187842589 @default.
- W2575488534 hasRelatedWork W1984364643 @default.
- W2575488534 hasRelatedWork W1994050787 @default.
- W2575488534 hasRelatedWork W2009244638 @default.
- W2575488534 hasRelatedWork W2087976276 @default.
- W2575488534 hasRelatedWork W2113148377 @default.
- W2575488534 hasRelatedWork W2358946826 @default.
- W2575488534 hasRelatedWork W2369676305 @default.
- W2575488534 hasRelatedWork W2391993467 @default.
- W2575488534 hasRelatedWork W2418172494 @default.
- W2575488534 hasVolume "127" @default.
- W2575488534 isParatext "false" @default.
- W2575488534 isRetracted "false" @default.
- W2575488534 magId "2575488534" @default.
- W2575488534 workType "article" @default.