FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575500684> ?p ?o ?g. }

• W2575500684 abstract "Abstract Abstract 1014 All sickle cell anemia patients (HbSS, SCA) have the same genetic mutation, but the clinical phenotype is highly variable and difficult to predict prior to the onset of disease complications. If severe SCA could be predicted early in life, then disease modifying therapies could be instituted prior to the onset of organ damage. To determine if reticulocyte levels in SCA patients are useful in disease severity prediction, a convenience sample of 50 children with SCA was enrolled in an observational study. After consent and assent were obtained, discarded peripheral blood obtained during routine clinic visits was collected and analyzed within 48 hours of collection and storage at 4°C. Hematologic data, including absolute reticulocyte counts (ARC), was collected using a Sysmex Hematology Analyzer. Clinical events were examined prospectively from the time of enrollment and retrospectively if the patient had events prior to study enrollment. Clinical events included: painful crises requiring hospital admission (VOC), acute chest syndrome, and splenic sequestration that occurred prior to the onset of chronic therapy. ARC and hematologic data were collected over time and analyzed using Cox regression analysis to determine the relationship between ARC levels and time to the first event. To evaluate the utility of ARC in risk stratification, patients were divided into two groups: ARC less than 200K/uL (ARC<200) and ARC greater than or equal to 200K/uL (ARC≥200). Initial analyses were performed using steady state ARCs prior to the first clinical event (pre-event baseline ARC). Steady state was defined as a sample collected at least 30 days from an acute illness and at least 60 days since the patient received a blood transfusion. Patients were followed an average of 6.7 years (range 0.82–16.8 years), which provides 332 person years of follow-up. A time dependent Cox regression analysis of pre-event baseline ARC≥200 compared with ARC<200 over the first 3 years of life generated a hazard ratio of having a first clinical event of 4.7 [95%CI 1.83–12.29 (p=0.0013)]. Maximum ARC before age 6 months (defined as the infant baseline ARC) was utilized for additional analyses. Cox regression analysis revealed that those subjects with an infant baseline ARC≥200 had 3.2 times the risk of having an event within the first 3 years of life than the group with an infant baseline ARC<200 (HR 3.15, 95%CI 1.54–6.45, p=0.0017). Forty-eight percent (12/25) of patients with an infant baseline ARC <200 had an event by age 3 years compared to 88% (22/25) of patients in the ARC≥200 group (p=0.001). The number of events per patient years was higher in the infant baseline ARC≥200 group (0.74 events/patient years of follow up vs. infant baseline ARC<200, 0.29 events/patient years of follow up, p=0.0004). The median time to first event in the infant baseline ARC≥200 group was shorter [1.39 years (95% CI 0.87–1.93)] than the baseline ARC<200 group [3.06 years (95%CI 1.71–3.80)]. These data suggest that both pre-event and infant baseline ARCs assist with risk stratification in infants and young children with SCA. Further studies are needed to determine if ARC risk stratification assessments are sufficiently robust for the guidance of treatment decisions for pediatric SCA. Disclosures: No relevant conflicts of interest to declare." @default.
• W2575500684 created "2017-01-26" @default.
• W2575500684 creator A5000449507 @default.
• W2575500684 creator A5005769736 @default.
• W2575500684 creator A5052306699 @default.
• W2575500684 creator A5064642922 @default.
• W2575500684 date "2012-11-16" @default.
• W2575500684 modified "2023-09-28" @default.
• W2575500684 title "Risk Stratification in Pediatric Sickle Cell Disease Using Absolute Reticulocyte Counts" @default.
• W2575500684 doi "https://doi.org/10.1182/blood.v120.21.1014.1014" @default.
• W2575500684 hasPublicationYear "2012" @default.
• W2575500684 type Work @default.
• W2575500684 sameAs 2575500684 @default.
• W2575500684 citedByCount "0" @default.
• W2575500684 crossrefType "journal-article" @default.
• W2575500684 hasAuthorship W2575500684A5000449507 @default.
• W2575500684 hasAuthorship W2575500684A5005769736 @default.
• W2575500684 hasAuthorship W2575500684A5052306699 @default.
• W2575500684 hasAuthorship W2575500684A5064642922 @default.
• W2575500684 hasConcept C104317684 @default.
• W2575500684 hasConcept C105580179 @default.
• W2575500684 hasConcept C126322002 @default.
• W2575500684 hasConcept C185592680 @default.
• W2575500684 hasConcept C187212893 @default.
• W2575500684 hasConcept C194409129 @default.
• W2575500684 hasConcept C2778248108 @default.
• W2575500684 hasConcept C2778403015 @default.
• W2575500684 hasConcept C2778620579 @default.
• W2575500684 hasConcept C2779134260 @default.
• W2575500684 hasConcept C2780976302 @default.
• W2575500684 hasConcept C50382708 @default.
• W2575500684 hasConcept C55493867 @default.
• W2575500684 hasConcept C71924100 @default.
• W2575500684 hasConceptScore W2575500684C104317684 @default.
• W2575500684 hasConceptScore W2575500684C105580179 @default.
• W2575500684 hasConceptScore W2575500684C126322002 @default.
• W2575500684 hasConceptScore W2575500684C185592680 @default.
• W2575500684 hasConceptScore W2575500684C187212893 @default.
• W2575500684 hasConceptScore W2575500684C194409129 @default.
• W2575500684 hasConceptScore W2575500684C2778248108 @default.
• W2575500684 hasConceptScore W2575500684C2778403015 @default.
• W2575500684 hasConceptScore W2575500684C2778620579 @default.
• W2575500684 hasConceptScore W2575500684C2779134260 @default.
• W2575500684 hasConceptScore W2575500684C2780976302 @default.
• W2575500684 hasConceptScore W2575500684C50382708 @default.
• W2575500684 hasConceptScore W2575500684C55493867 @default.
• W2575500684 hasConceptScore W2575500684C71924100 @default.
• W2575500684 hasLocation W25755006841 @default.
• W2575500684 hasOpenAccess W2575500684 @default.
• W2575500684 hasPrimaryLocation W25755006841 @default.
• W2575500684 hasRelatedWork W200083443 @default.
• W2575500684 hasRelatedWork W2171197110 @default.
• W2575500684 hasRelatedWork W2520084393 @default.
• W2575500684 hasRelatedWork W2521973717 @default.
• W2575500684 hasRelatedWork W2550086415 @default.
• W2575500684 hasRelatedWork W2557362376 @default.
• W2575500684 hasRelatedWork W2566838589 @default.
• W2575500684 hasRelatedWork W2573491605 @default.
• W2575500684 hasRelatedWork W2794394975 @default.
• W2575500684 hasRelatedWork W284346629 @default.
• W2575500684 hasRelatedWork W2901334784 @default.
• W2575500684 hasRelatedWork W2959972968 @default.
• W2575500684 hasRelatedWork W2968638723 @default.
• W2575500684 hasRelatedWork W2983619134 @default.
• W2575500684 hasRelatedWork W2985745889 @default.
• W2575500684 hasRelatedWork W2989812973 @default.
• W2575500684 hasRelatedWork W3006603982 @default.
• W2575500684 hasRelatedWork W3012242580 @default.
• W2575500684 hasRelatedWork W3092984339 @default.
• W2575500684 hasRelatedWork W3097938016 @default.
• W2575500684 isParatext "false" @default.
• W2575500684 isRetracted "false" @default.
• W2575500684 magId "2575500684" @default.
• W2575500684 workType "article" @default.