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- W2575606523 abstract "1738 Objectives Current NIST traceable Ge-68 dose calibrator sources are linked to dated NIST F-18 measurements, introducing ~4% bias in F-18 dose calibrator measurements. This situation results in discordant PET/CT measurements of Ga-68, F-18, and other positron-emitters. This study validates a PET/CT scanner calibration method based upon Ga-68 measurements, traceable to the NIST Ge-68 standard, rather than F-18. Methods After calibrating the dose calibrator with a NIST traceable Ge-68 syringe source, a cross-calibration of the PET scanner was performed using a phantom with known Ga-68 activity. Once the PET scanner was calibrated for Ga-68, a uniform aqueous phantom was filled with F-18 (activity measured using the standard gain recommended by the dose calibrator vendor). Upon PET imaging and reconstruction, a volume of interest from the phantom PET image was analyzed for its scanner derived mean concentration, and compared to the dose calibrator-based concentration. The resulting bias was then used to back-correct the dose calibrator gain setting for F-18, accordingly. Finally, the gain settings for other common positron-emitting radionuclides without prompt gammas, (C-11, N-13, and O-15) were adjusted relative to F-18 activities according to their positron emission branching ratios. Results The observed 4% discrepancy between the quantitative measurements of PET derived concentrations from uniform phantom images using different positron-emitting radionuclides due to inaccuracies from the conventional cross-calibration method was successfully reduced to ~1% by using the quantitative measurement capabilities of the PET scanner to generate proper radionuclide-specific gain settings for the dose calibrator. Conclusions Until new NIST traceable sources integrate the newer and more accurate F-18 measurements for dose calibrator calibration, the proposed method promises better accuracy and consistency for a range of positron-emitting radionuclides." @default.
- W2575606523 created "2017-01-26" @default.
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- W2575606523 date "2015-05-01" @default.
- W2575606523 modified "2023-09-24" @default.
- W2575606523 title "A new method for positron-emitting radionuclide cross-calibration of PET/CT scanners and dose calibrators from a NIST traceable Ge-68 source." @default.
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