FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575644119> ?p ?o ?g. }

• W2575644119 endingPage "1637" @default.
• W2575644119 startingPage "1627" @default.
• W2575644119 abstract "Many pulmonary infections elicit lymphocyte responses that lead to an accumulation of granulocytes in the lungs. A variety of lymphocytes are capable of directing eosinophils or neutrophils to the lungs, but the contribution of each subset remains enigmatic. In this study, we used a murine model to examine lymphocyte subsets that ultimately drive the eosinophil or neutrophil response to infection with the fungal pathogen Cryptococcus neoformans. We show that granulocytes are produced in the bone marrow, released into the blood stream, and accumulate in the lungs under the instruction of lung parenchymal lymphocytes. The eosinophils that populated the lungs of wild-type animals were highly dependent on Th cells or IL-5. Surprisingly, infected mice with Th cell impairment experienced a compensatory neutrophil response that required IL-17A. This unexpected swing in the response prompted us to investigate the ability of different lymphocyte subsets to produce this dichotomous eosinophilia or neutrophilia. We used mice with lymphocyte deficiencies to determine which of the remaining IL-5- or IL-17A-producing lymphocyte subsets dominated the neutrophil or eosinophil response. Finally, skewing the response toward neutrophil-inducing lymphocytes correlated with accelerated disease. Our data collectively demonstrate that the predominance of a lymphocyte subset determines the functional consequences of an immune response to pulmonary fungal infection that can ultimately affect disease." @default.
• W2575644119 created "2017-01-26" @default.
• W2575644119 creator A5013433963 @default.
• W2575644119 creator A5022507193 @default.
• W2575644119 creator A5035282230 @default.
• W2575644119 creator A5053523694 @default.
• W2575644119 creator A5064240631 @default.
• W2575644119 date "2017-02-15" @default.
• W2575644119 modified "2023-10-16" @default.
• W2575644119 title "Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary <i>Cryptococcus</i> Infection" @default.
• W2575644119 cites W1501602460 @default.
• W2575644119 cites W1602437032 @default.
• W2575644119 cites W1620097935 @default.
• W2575644119 cites W1898649886 @default.
• W2575644119 cites W1920211008 @default.
• W2575644119 cites W1953168141 @default.
• W2575644119 cites W1965734808 @default.
• W2575644119 cites W1967994686 @default.
• W2575644119 cites W1982229304 @default.
• W2575644119 cites W1989286818 @default.
• W2575644119 cites W1993734178 @default.
• W2575644119 cites W2002836781 @default.
• W2575644119 cites W2005361432 @default.
• W2575644119 cites W2007027030 @default.
• W2575644119 cites W2011325395 @default.
• W2575644119 cites W2012077729 @default.
• W2575644119 cites W2016616221 @default.
• W2575644119 cites W2025131995 @default.
• W2575644119 cites W2032227357 @default.
• W2575644119 cites W2034453891 @default.
• W2575644119 cites W2037123168 @default.
• W2575644119 cites W2037319487 @default.
• W2575644119 cites W2049426078 @default.
• W2575644119 cites W2051348897 @default.
• W2575644119 cites W2054253853 @default.
• W2575644119 cites W2058856567 @default.
• W2575644119 cites W2069375519 @default.
• W2575644119 cites W2075063917 @default.
• W2575644119 cites W2079513681 @default.
• W2575644119 cites W2088102919 @default.
• W2575644119 cites W2089782191 @default.
• W2575644119 cites W2090263431 @default.
• W2575644119 cites W2094558708 @default.
• W2575644119 cites W2094786750 @default.
• W2575644119 cites W2095753163 @default.
• W2575644119 cites W2097384956 @default.
• W2575644119 cites W2104934425 @default.
• W2575644119 cites W2115070707 @default.
• W2575644119 cites W2120277859 @default.
• W2575644119 cites W2121327269 @default.
• W2575644119 cites W2129148340 @default.
• W2575644119 cites W2135152690 @default.
• W2575644119 cites W2140473547 @default.
• W2575644119 cites W2147711737 @default.
• W2575644119 cites W2149589945 @default.
• W2575644119 cites W2152014155 @default.
• W2575644119 cites W2155792963 @default.
• W2575644119 cites W2159913536 @default.
• W2575644119 cites W2160702475 @default.
• W2575644119 cites W2160883911 @default.
• W2575644119 cites W2162283579 @default.
• W2575644119 cites W2166414010 @default.
• W2575644119 cites W2167524229 @default.
• W2575644119 cites W2180417618 @default.
• W2575644119 cites W2219027175 @default.
• W2575644119 cites W4211253912 @default.
• W2575644119 doi "https://doi.org/10.4049/jimmunol.1600821" @default.
• W2575644119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5296217" @default.
• W2575644119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28069805" @default.
• W2575644119 hasPublicationYear "2017" @default.
• W2575644119 type Work @default.
• W2575644119 sameAs 2575644119 @default.
• W2575644119 citedByCount "29" @default.
• W2575644119 countsByYear W25756441192017 @default.
• W2575644119 countsByYear W25756441192018 @default.
• W2575644119 countsByYear W25756441192019 @default.
• W2575644119 countsByYear W25756441192020 @default.
• W2575644119 countsByYear W25756441192022 @default.
• W2575644119 countsByYear W25756441192023 @default.
• W2575644119 crossrefType "journal-article" @default.
• W2575644119 hasAuthorship W2575644119A5013433963 @default.
• W2575644119 hasAuthorship W2575644119A5022507193 @default.
• W2575644119 hasAuthorship W2575644119A5035282230 @default.
• W2575644119 hasAuthorship W2575644119A5053523694 @default.
• W2575644119 hasAuthorship W2575644119A5064240631 @default.
• W2575644119 hasBestOaLocation W25756441191 @default.
• W2575644119 hasConcept C109159458 @default.
• W2575644119 hasConcept C203014093 @default.
• W2575644119 hasConcept C2776042228 @default.
• W2575644119 hasConcept C2777037409 @default.
• W2575644119 hasConcept C2777129736 @default.
• W2575644119 hasConcept C2777761686 @default.
• W2575644119 hasConcept C2777802486 @default.
• W2575644119 hasConcept C2777983669 @default.
• W2575644119 hasConcept C28328180 @default.
• W2575644119 hasConcept C54355233 @default.
• W2575644119 hasConcept C86803240 @default.
• W2575644119 hasConcept C8891405 @default.

• next