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- W2575681749 abstract "Alzheimer’s disease (AD) is a terminal disease, also considered a type of dementia, which results from progressive neurodegeneration in different parts of the brain due to misregulation of various biochemical factors. The current drug therapies that target these factors could not sustain the treatment in long term due to resultant side-effects, and the trials in the later stage of the disease have failed due to excessive neuronal loss. Therefore, neural stem cells, cells that could differentiate into different types of cells in the nervous system given appropriate cues could be utilized tackle these problems. In this chapter, the diffuse pathology of AD which accounts for the disease complexity and its therapeutic challenge will be reviewed. Furthermore, the use of different models to study the disease pathology and its treatment with stem cell will be highlighted. Finally, different stem cell types for AD treatment in animal models and the research advances in stem cell technology, as well as the future challenge for stem cell therapy to enable long-term treatment will be discussed." @default.
- W2575681749 created "2017-01-26" @default.
- W2575681749 creator A5026696939 @default.
- W2575681749 date "2017-01-01" @default.
- W2575681749 modified "2023-09-27" @default.
- W2575681749 title "Stem Cells in Alzheimer’s Disease Therapy" @default.
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- W2575681749 doi "https://doi.org/10.1007/978-3-319-33720-3_3" @default.
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